Relationship between Serum Asymmetric Dimethylarginine Level and Microvascular Complications in Diabetes Mellitus: A Meta-Analysis
المؤلفون المشاركون
Liu, Jing
Li, Caiying
Chen, Wen
He, Kuanrong
Ma, Huijuan
Ma, Boqing
Zhao, Pei
Tian, Lu
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
The purpose of the meta-analysis was to evaluate the relationship between serum asymmetric dimethylarginine (ADMA) level and microvascular complications in diabetes mellitus (DM) including diabetic retinopathy (DR), diabetic neuropathy (DN), and diabetic nephropathy.
Methods.
Studies were comprehensively identified by searching Web of Science, Embase, and PubMed databases up to August 30, 2018.
The meta-analysis was carried out to compare the difference of serum ADMA concentrations of DR, DN, and diabetic nephropathy patients with healthy controls.
The Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality were applied to assess the methodological quality.
Chi-squared Q test and I2 statistics were applied to evaluate statistical heterogeneity.
Subgroup analyses were conducted and publication bias was assessed by Egger’s test.
Result.
Ten studies were finally entered in the meta-analysis.
Statistically significant heterogeneity was observed across these studies ( I 2 = 77.0%, p < 0.001).
Compared with DM without microvascular complications, circulating level of ADMA was significantly higher in DM with microvascular complications (all p < 0.05).
Sensitivity analysis suggested that the results of this meta-analysis were shown to be stable.
There was no significant publication bias (P=0.823).
Conclusion.
Elevated ADMA levels correlate with diabetic microangiopathies such as DR and diabetic nephropathy.
ADMA may play an important role in the pathobiology of microvascular complications of diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Jing& Li, Caiying& Chen, Wen& He, Kuanrong& Ma, Huijuan& Ma, Boqing…[et al.]. 2019. Relationship between Serum Asymmetric Dimethylarginine Level and Microvascular Complications in Diabetes Mellitus: A Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1124204
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Jing…[et al.]. Relationship between Serum Asymmetric Dimethylarginine Level and Microvascular Complications in Diabetes Mellitus: A Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1124204
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Jing& Li, Caiying& Chen, Wen& He, Kuanrong& Ma, Huijuan& Ma, Boqing…[et al.]. Relationship between Serum Asymmetric Dimethylarginine Level and Microvascular Complications in Diabetes Mellitus: A Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1124204
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124204
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر