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Prognostic Significance of Neutrophil-to-Lymphocyte Ratio for Repeat Cerclage in Women with Prolapsed Membranes
المؤلفون المشاركون
Song, Ji Eun
Lee, Keun Young
Son, Ga Hyun
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-16
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
Cerclage is a surgical option for preventing preterm birth (PTB).
Repeat cerclage (RC) could prevent impending PTB in women with prolapsed membrane who already had primary cerclage.
PTB is associated with a state of inflammation.
It has been widely known that neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) reflect systemic inflammation.
We aimed to investigate whether NLR and PLR could be used as reliable markers in predicting pregnancy outcome following RC.
Methods.
The study group consisted of 26 patients, who underwent RC resulting from prolapsed membrane after primary cerclage.
NLR and PLR at the time of primary cerclage and RC were calculated.
ROC curve analysis and multivariate analysis were performed for determining predictive factors.
The study group was divided into two groups according to NLR 4.7 at RC: High NLR group was defined as NLR > 4.7, and low NLR group was defined as NLR ≤ 4.7.
We compared pregnancy outcomes, such as delivery at gestational age, and rate of delivery < 28 weeks between two groups.
Results.
The average gestational age at primary cerclage was 15.7 weeks, and the mean gestational age at RC was 21.0 weeks.
NLR at RC was significantly elevated when compared with NLR at primary cerclage (NLR, 4.0 vs.
8.9, p=0.001), but there was no significant difference in terms of PLR (p=0.07).
ROC curve showed that there was a significant prediction power of NLR at RC for delivery < 28 weeks (AUC, 0.91; p<0.01).
Using NLR cut-off of 4.7, 8 had NLR ≤ 4.7 (low NLR group), whereas 18 had NLR > 4.7 (high NLR group).
High NLR group showed worse pregnancy outcome compared to low NLR group: there were significant differences in gestational age at delivery, and neonatal survival rate between two groups (31.5 weeks vs.
25.9 weeks, p=0.02; 100% (8/8) vs.
55.6% (10/18), p=0.03, respectively).
Survival analysis demonstrated a lower incidence of delivery < 28 weeks of gestation in low NLR group compared with high NLR group (p<0.01, log-rank test).
Conclusion.
NLR might be used as a reliable factor for predicting pregnancy outcome following RC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Ji Eun& Lee, Keun Young& Son, Ga Hyun. 2018. Prognostic Significance of Neutrophil-to-Lymphocyte Ratio for Repeat Cerclage in Women with Prolapsed Membranes. BioMed Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1124390
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Ji Eun…[et al.]. Prognostic Significance of Neutrophil-to-Lymphocyte Ratio for Repeat Cerclage in Women with Prolapsed Membranes. BioMed Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1124390
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Ji Eun& Lee, Keun Young& Son, Ga Hyun. Prognostic Significance of Neutrophil-to-Lymphocyte Ratio for Repeat Cerclage in Women with Prolapsed Membranes. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1124390
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124390
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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