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GeneXpert MTBRIF Outperforms Mycobacterial Culture in Detecting Mycobacterium tuberculosis from Salivary Sputum
المؤلفون المشاركون
Huang, Hairong
Pang, Yu
Shi, Jin
Dong, Wenzhu
Ma, Yifeng
Liang, Qian
Shang, Yuanyuan
Wang, Fen
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-01
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
GeneXpert MTB/RIF (Xpert) assay has been endorsed for the diagnosis of pulmonary TB due to its high sensitivity and specificity for culture positive TB.
There is no doubt that Xpert could not be more sensitive than mycobacterial culture, while the positive rate of Xpert among sputum samples was higher than that of mycobacterial culture in our laboratory.
We therefore carried out a prospective study to determine a potential explanation for this unexpected result regarding the clinical use of Xpert.
Overall, a total of 558 patients meeting inclusion criteria were enrolled in final analysis between August 2017 and September 2017 in Beijing Chest Hospital.
The overall positive rate of Xpert among sputum samples was 45.9% (256/558), which was significantly higher than that of liquid culture (33.4%, 184/558; P < 0.01 ).
The percentage of culture negative result in salivary sputum was significantly higher than that in mucoid sputum [odds ratio (OR): 5.04, 95% confidence interval (95% CI): 2.74–9.28; P < 0.01 ].
In addition, the TB cases having previous treatment history had a higher proportion of culture negative result than new cases (OR: 4.26, 95% CI: 1.61–11.28; P = 0.01 ).
In conclusion, the results of this study demonstrate that Xpert outperforms mycobacterial culture in detecting MTB from salivary sputum.
In addition, the previously treated patients are more likely to yield negative culture results.
Our data will provide important hints to formulate an appropriate diagnostic algorithm for pulmonary tuberculosis based on the appearance of sputum samples.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Jin& Dong, Wenzhu& Ma, Yifeng& Liang, Qian& Shang, Yuanyuan& Wang, Fen…[et al.]. 2018. GeneXpert MTBRIF Outperforms Mycobacterial Culture in Detecting Mycobacterium tuberculosis from Salivary Sputum. BioMed Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1124401
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Jin…[et al.]. GeneXpert MTBRIF Outperforms Mycobacterial Culture in Detecting Mycobacterium tuberculosis from Salivary Sputum. BioMed Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1124401
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Jin& Dong, Wenzhu& Ma, Yifeng& Liang, Qian& Shang, Yuanyuan& Wang, Fen…[et al.]. GeneXpert MTBRIF Outperforms Mycobacterial Culture in Detecting Mycobacterium tuberculosis from Salivary Sputum. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1124401
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124401
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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