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Reevaluating the Role of Corticosteroids in Septic Shock: An Updated Meta-Analysis of Randomized Controlled Trials
المؤلفون المشاركون
He, Pengcheng
Liu, Yuanhui
Lian, X.-J.
Huang, D.-Z.
Cao, Y.-S.
Wei, Y.-X.
Lian, Z.-Z.
Qin, T.-H.
Wang, S.-H.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-10
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
What Is Known and Objective.
To reevaluate the benefits and risks of corticosteroid treatment in adult patients with septic shock.
Methods.
This study was performed based on PRISMA guidelines.
Randomized controlled trials (RCTs) of corticosteroids versus placebo were retrieved from PubMed, MEDLINE, EMBASE, Web of Science, the Cochrane Central RCTs, and ClinicalTrials.gov from January 1980 to April 2018.
We also conducted a trial sequential analysis to indicate the possibility of type I or II errors and calculate the information size.
Grading of Recommendations, Assessment, Development and Evaluation approach (GRADE) was applying to assess the certainty of evidence at the primary outcome level.
Results.
Twenty-one RCTs were identified and analyzed.
Patients treated with corticosteroid had a 7% reduction in relative risk in 28-day all-cause mortality compared to controls (RR 0.93, 95% CI 0.88 to 0.99).
However, there were no significant differences for the intensive care unit (ICU) mortality (RR 0.97, 95% CI 0.86 to 1.09) or in-hospital mortality (RR 1.01, 95% CI 0.92 to 1.11).
Corticosteroids shortened the length of ICU stay by 1.04 days (RR -1.04, 95% CI -1.72 to -0.36) and the length of hospital stay by 2.49 days (RR -2.49, 95% CI -4.96 to -0.02).
Corticosteroids increased the risk of hyperglycemia (RR 1.11, 95% CI 1.06 to 1.16) but not gastroduodenal bleeding (RR 1.06, 95% CI 0.82 to 1.37) or superinfection (RR 1.04, 95% CI 0.94 to 1.15).
However, some date on secondary outcomes were unavailable because they were not measured or not reported in the included studies which may cause a lack of power or selective outcome reporting.
The information size was calculated at 10044 patients.
Trial sequential analysis showed that the meta-analysis was conclusive and the risk of type 2 error was minimal.
What Is New and Conclusion.
Corticosteroids are likely to be effective in reducing 28-day mortality and attenuating septic shock without increasing the rate of life-threatening complications.
TSA showed that the risk of type II error in this meta-analysis was minimal and the result was conclusive.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lian, X.-J.& Huang, D.-Z.& Cao, Y.-S.& Wei, Y.-X.& Lian, Z.-Z.& Qin, T.-H.…[et al.]. 2019. Reevaluating the Role of Corticosteroids in Septic Shock: An Updated Meta-Analysis of Randomized Controlled Trials. BioMed Research International،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1124427
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lian, X.-J.…[et al.]. Reevaluating the Role of Corticosteroids in Septic Shock: An Updated Meta-Analysis of Randomized Controlled Trials. BioMed Research International No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1124427
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lian, X.-J.& Huang, D.-Z.& Cao, Y.-S.& Wei, Y.-X.& Lian, Z.-Z.& Qin, T.-H.…[et al.]. Reevaluating the Role of Corticosteroids in Septic Shock: An Updated Meta-Analysis of Randomized Controlled Trials. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1124427
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124427
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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