Role of MAPKs in HSP70’s Protection against Heat Stress-Induced Injury in Rat Small Intestine
المؤلفون المشاركون
Hao, Yue
Feng, Yuejin
Li, Jielei
Gu, Xianhong
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aim.
To evaluate the role of heat shock protein 70 (HSP70) on the MAPK pathway activation with quercetin treatment and its protection against small intestine impairments of heat stressed rats.
Methods.
Forty-eight male Sprague-Dawley rats aged 6 weeks were randomized to three groups (n=16/group), namely, control (CON), heat stress (HS), and heat stress + quercetin (HQ).
The experiment lasted for 14 days with daily 50 min of heat stress treatment (43°C) for the HS and HQ groups.
Rats of HQ group were intragastrically given 0.5 ml quercetin solution (50 mg/kg body weight) before the heat stress treatment.
Half of the animals were sacrificed on day 7 and the rest on day 14 for tissue sampling.
Intestinal morphology, small intestine morphology and permeability, protein expression of HSP70, phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and caspase-3 activity were examined.
Results.
Heat stress caused morphological damage to the small intestine and increased intestinal permeability.
HSP70 expression and MAPK activity in the small intestine were increased by heat stress.
Inhibition of HSP70 by quercetin did not change intestinal permeability compared with the HS group but aggravated intestinal injury and affected the activation of MAPKs and caspase-3.
Conclusions.
HSP70 may modulate stress-activated signaling and acts in a protective manner via MAPK signaling.
Affecting HSP70 protective mechanisms could be useful for protection against heat stress-induced injury in rat small intestine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hao, Yue& Feng, Yuejin& Li, Jielei& Gu, Xianhong. 2018. Role of MAPKs in HSP70’s Protection against Heat Stress-Induced Injury in Rat Small Intestine. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1124475
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hao, Yue…[et al.]. Role of MAPKs in HSP70’s Protection against Heat Stress-Induced Injury in Rat Small Intestine. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1124475
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hao, Yue& Feng, Yuejin& Li, Jielei& Gu, Xianhong. Role of MAPKs in HSP70’s Protection against Heat Stress-Induced Injury in Rat Small Intestine. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1124475
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124475
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر