Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTENAKT Pathway via Promoting Ras Homolog Family Member B (RhoB)
المؤلفون المشاركون
Ma, Qing
Gao, Yang
Xu, Pei
Li, Kai
Xu, Xiaolong
Gao, Jingbo
Qi, Yuwen
Xu, Jingjing
Yang, Yan
Song, Wenjing
He, Xin
Liu, Shuting
Yuan, Xiaoning
Yin, Weinan
He, Yanqi
Pan, Wenting
Wei, Lei
Zhang, Jingwei
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-18
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Background.
Breast cancer (BC) is one of the most common malignant tumors in women around the world.
Atorvastatin (ATO) was found to be associated with a decreased risk of recurrence and mortality in cancer.
But the exact mechanism of its carcinostatic effects is unclear.
The expression level of Ras homolog family member B (RhoB) in breast cancer cells was found to be upregulated after being treated with ATO.
Thus, we conjecture that altered expression of RhoB induced by ATO may be decisive for the migration and progression of breast cancer.
Methods.
The effects of ATO on breast tumor cells in vivo and in vitro were detected by clone formation assay, CCK-8 assay, flow cytometry, wound healing, transwell assays, tumor xenograft model, and immunohistochemistry.
Distribution of RhoB in different breast cancer tissues and its influence on prognosis were analyzed using the data from TCGA or GEO databases.
The relationship between RhoB and PTEN/AKT pathway was detected by Western blotting and RT-qPCR.
Results.
ATO inhibits proliferation, invasion, EMT, and PTEN/AKT pathway and promotes apoptosis in breast tumor cells.
In addition, ATO inhibits the volume and weight of breast tumor in tumor-bearing mice and upregulated RhoB in tumor tissues.
The expression of RhoB in mRNA and protein level was upregulated in statin-treated breast cancer cells and downregulated in cancer tissues.
Low expression of RhoB links with poor prognosis in patients with breast cancer (HR = 0.74[0.66–0.83], p =7e−8, log-rank test).
Further research found that RhoB inhibits the proliferation, invasion, EMT, and PTEN/AKT signal pathway in breast tumor cells.
Conclusions.
The exact mechanism of ATO’s carcinostatic effects in breast cancer is related to downregulating PTEN/AKT pathway via promoting RhoB.
Our study also demonstrates the potential applicability of RhoB as a therapeutic target for breast cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Qing& Gao, Yang& Xu, Pei& Li, Kai& Xu, Xiaolong& Gao, Jingbo…[et al.]. 2019. Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTENAKT Pathway via Promoting Ras Homolog Family Member B (RhoB). BioMed Research International،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1124485
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Qing…[et al.]. Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTENAKT Pathway via Promoting Ras Homolog Family Member B (RhoB). BioMed Research International No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1124485
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Qing& Gao, Yang& Xu, Pei& Li, Kai& Xu, Xiaolong& Gao, Jingbo…[et al.]. Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTENAKT Pathway via Promoting Ras Homolog Family Member B (RhoB). BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1124485
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124485
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر