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Functional Probiotic Assessment and In Vivo Cholesterol-Lowering Efficacy of Weissella sp. Associated with Arid Lands Living-Hosts
المؤلفون المشاركون
Fhoula, Imene
Najjari, Afef
Boudabous, Abdelatif
Ouzari, Hadda
Rehaiem, Amel
Usai, Donatella
Sechi, Leonardo Antonio
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-14
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The research and the selection of novel probiotic strains from novel niches are receiving increased attention on their proclaimed health benefits to both humans and animals.
This study aimed to evaluate the functional properties of Weissella strains from arid land living-hosts and to select strains with cholesterol-lowering property in vitro and in vivo, for use as probiotics.
They were assessed for acid and bile tolerance, antibiotic susceptibility, membrane properties, antibacterial activity, antiadhesive effect against pathogens to host cell lines, and cholesterol assimilation in vitro.
Our results showed that the majority of strains revealed resistance to gastrointestinal conditions.
All the strains were nonhemolytic and sensitive to most of the tested antibiotics.
They also exhibited high rates of autoaggregation and some of them showed high coaggregation with selected pathogens and high adhesion ability to two different cell lines (Caco-2 and MIM/PPk).
Particularly, W.
halotolerans F99, from camel feces, presented a broad antibacterial spectrum against pathogens, reduced Enterococcus faecalis and Escherichia coli adhesion to Caco-2 cells, and was found to reduce, in vitro, the cholesterol level by 49 %.
Moreover, W.
halotolerans F99 was evaluated for the carbohydrate utilization as well as the serum lipid metabolism effect in Wistar rats fed a high-cholesterol diet.
W.
halotolerans F99 showed an interesting growth on different plant-derivative oligosaccharides as sole carbon sources.
Compared with rats fed a high-fat (HF) diet without Weissella administration, total serum cholesterol, low-density lipoprotein cholesterol, and triglycerides levels were significantly (p<0.001) reduced in W.
halotolerans F99-treated HF rats, with no significant change in high-density lipoprotein cholesterol HDL-C levels.
On the basis of these results, this is the first study to report that W.
halotolerans F99, from camel feces, can be developed as cholesterol-reducing probiotic strain.
Further studies may reveal their potential and possible biotechnological and probiotic applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fhoula, Imene& Rehaiem, Amel& Najjari, Afef& Usai, Donatella& Boudabous, Abdelatif& Sechi, Leonardo Antonio…[et al.]. 2018. Functional Probiotic Assessment and In Vivo Cholesterol-Lowering Efficacy of Weissella sp. Associated with Arid Lands Living-Hosts. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1124549
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fhoula, Imene…[et al.]. Functional Probiotic Assessment and In Vivo Cholesterol-Lowering Efficacy of Weissella sp. Associated with Arid Lands Living-Hosts. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1124549
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fhoula, Imene& Rehaiem, Amel& Najjari, Afef& Usai, Donatella& Boudabous, Abdelatif& Sechi, Leonardo Antonio…[et al.]. Functional Probiotic Assessment and In Vivo Cholesterol-Lowering Efficacy of Weissella sp. Associated with Arid Lands Living-Hosts. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1124549
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124549
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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