Prognostic Value of Lactate Dehydrogenase in Patients with Hepatocellular Carcinoma: A Meta-Analysis
المؤلفون المشاركون
Kong, Weihao
Zuo, Xiaomin
Liang, Hao
Hu, Jingxiong
Zhang, Huabing
Wang, Xingyu
Chen, Wei
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Previous studies have shown the prognostic value of lactate dehydrogenase (LDH) in hepatocellular carcinoma (HCC), but the results are not persuasive.
Therefore, the purpose of our study was to quantitatively explore the prognostic value of LDH in hepatocellular carcinoma.
Methods.
We searched the Web of Science, Embase, PubMed, and the Cochrane Library for literature published before October 2018 on the prognostic value of LDH in patients with hepatocellular carcinoma.
The combined hazard ratios (HRs) and 95% confidence intervals (CIs) were utilized to assess the prognostic value of LDH in overall survival (OS), recurrence-free survival (RFS), and progression-free survival (PFS) of HCC.
Subgroup analysis, sensitivity analysis, and metaregression were used to explore the source of heterogeneity.
Funnel plots with Begg’s test and Egger’s test were used to detect potential publication biases.
Furthermore, combined odds ratios (ORs) were utilized to assess the correlation between LDH and clinicopathological features.
Results.
A total of 10 nonrandomized controlled studies were included in this meta-analysis.
The combined effects of LDH on HCC patients’ OS, RFS/DFS, and PFS were HR = 2.07, 95% CI: 1.63-2.62, P < 0.001; HR = 1.62, 95% CI: 1.37-1.90, P < 0.001; and HR = 1.96, 95% CI: 1.14-3.36, P = 0.014, respectively.
Subgroup analysis and sensitivity analysis showed that the outcome was stable, and the results of the metaregression also identified statistical models as an important source of heterogeneity.
Potential publication bias was detected in the OS studies, so the trim-and-fill method was used to explore publication bias, and the results showed stability.
Furthermore, the combined OR suggests that LDH was significantly correlated with gender, Child-Pugh grade, alpha-fetoprotein, vascular invasion, and tumor size.
Conclusions.
Preoperative LDH elevation is significantly associated with poor prognosis in patients with HCC, which may be a promising factor in assessing the prognosis of patients with HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kong, Weihao& Zuo, Xiaomin& Liang, Hao& Hu, Jingxiong& Zhang, Huabing& Wang, Xingyu…[et al.]. 2018. Prognostic Value of Lactate Dehydrogenase in Patients with Hepatocellular Carcinoma: A Meta-Analysis. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1124601
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kong, Weihao…[et al.]. Prognostic Value of Lactate Dehydrogenase in Patients with Hepatocellular Carcinoma: A Meta-Analysis. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1124601
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kong, Weihao& Zuo, Xiaomin& Liang, Hao& Hu, Jingxiong& Zhang, Huabing& Wang, Xingyu…[et al.]. Prognostic Value of Lactate Dehydrogenase in Patients with Hepatocellular Carcinoma: A Meta-Analysis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1124601
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124601
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر