The Utility of 18F-FDG PETCT for Monitoring Response and Predicting Prognosis after Glucocorticoids Therapy for Sarcoidosis
المؤلفون المشاركون
Chen, Hengyi
Jin, Rongbing
Wang, Yubo
Li, Li
Li, Kunlin
He, Yong
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-01
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Sarcoidosis has significant heterogeneity involving multiple organs; treatment of the disease is a significant therapeutic challenge due to the difficulties in accurately monitoring disease activity and estimating prognosis.
Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) plays an important role in assessing the metabolic activity.
However, there is not enough evidence about the influence of this method in the clinical management and prognosis prediction for sarcoidosis.
This study aims to investigate the clinical utility of 18F-FDG PET/CT for therapeutic evaluation and prognostic prediction in sarcoidosis.
We had retrospectively enrolled 23 patients with sarcoidosis assigned to receive systemic glucocorticoids.
All patients underwent baseline 18F-FDG PET/CT before initiating therapy and follow-up 18F-FDG PET/CT within 3 months after the therapy.
The metabolic and clinical responses were classified.
The baseline 18F-FDG PET/CT showed increased uptake in all patients.
Based solely on biopsy-proven sites, the sensitivity of 18F-FDG PET/CT was 91.7%, and the sensitivity improved to 100% after excluding skin involvement.
In the subsequent follow-up PET scans within 3 months after glucocorticoids therapy, the SUVmax were variously decreased except one; there are significant differences in the clinical remission rates and the relapse rates between patients with a favorable response and cases with no response on follow-up PET scan, the increasing metabolic response was associated with the increase in clinical remission rates and the reduction in recurrence rates.
In conclusion, the present study shows that 18F-FDG PET/CT is an effective way to monitor the early therapeutic reaction and is helpful in predicting the long-term prognosis of sarcoidosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Hengyi& Jin, Rongbing& Wang, Yubo& Li, Li& Li, Kunlin& He, Yong. 2018. The Utility of 18F-FDG PETCT for Monitoring Response and Predicting Prognosis after Glucocorticoids Therapy for Sarcoidosis. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1124668
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Hengyi…[et al.]. The Utility of 18F-FDG PETCT for Monitoring Response and Predicting Prognosis after Glucocorticoids Therapy for Sarcoidosis. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1124668
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Hengyi& Jin, Rongbing& Wang, Yubo& Li, Li& Li, Kunlin& He, Yong. The Utility of 18F-FDG PETCT for Monitoring Response and Predicting Prognosis after Glucocorticoids Therapy for Sarcoidosis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1124668
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124668
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر