Factors That Predict the Growth of Residual Nonfunctional Pituitary Adenomas: Correlations between Relapse and Cell Cycle Markers
المؤلفون المشاركون
Buzrla, Petr
Lipina, Radim
Dvořáčková, Jana
Reguli, Štefan
Krajča, Jan
Matoušek, Petr
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Introduction.
Nonfunctional pituitary adenomas are treated surgically, and even partial resection can improve or eliminate clinical symptoms.
Notably, progression requires further intervention, which presents an increased risk, especially in older patients.
This study investigated whether the histopathological characteristics of nonfunctional adenomas could predict recurrence.
Materials and Methods.
Data were obtained retrospectively from 30 patients who underwent surgery for the partial resection of pituitary adenomas.
Remnant tumor growth was observed in 17 patients, while the residual tumor was unchanged more than 7 years after surgery in 13 patients.
Statistical analysis was performed to investigate correlations between remnant tumor progression and tumor histopathological findings, including protein expression of p21, p27, p53, and Ki-67.
Results and Discussion.
Remnant tumors that demonstrated regrowth showed significantly higher protein expression of p21 and Ki-67.
Expression of the p53 tumor suppressor was also higher in this group, but the difference was at the limit of statistical significance.
Conclusion.
Tumors with high expression of p21 and p53 and with a high Ki-67 index were more likely to show residual pituitary adenoma progression.
Such cases should undergo frequent radiological examination and timely reoperation, and radiosurgery should be considered.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Matoušek, Petr& Buzrla, Petr& Reguli, Štefan& Krajča, Jan& Dvořáčková, Jana& Lipina, Radim. 2018. Factors That Predict the Growth of Residual Nonfunctional Pituitary Adenomas: Correlations between Relapse and Cell Cycle Markers. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1124722
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Matoušek, Petr…[et al.]. Factors That Predict the Growth of Residual Nonfunctional Pituitary Adenomas: Correlations between Relapse and Cell Cycle Markers. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1124722
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Matoušek, Petr& Buzrla, Petr& Reguli, Štefan& Krajča, Jan& Dvořáčková, Jana& Lipina, Radim. Factors That Predict the Growth of Residual Nonfunctional Pituitary Adenomas: Correlations between Relapse and Cell Cycle Markers. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1124722
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124722
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر