Lead Induced Ototoxicity and Neurotoxicity in Adult Guinea Pig
المؤلفون المشاركون
Zhang, Yanni
Jiang, Qian
Xie, Shaobing
Wu, Xuewen
Zhou, Jun
Sun, Hong
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Lead exposure causes or aggravates hearing damage to human or animal, but the detailed effects of lead exposure on auditory system including injury sites of the cochlea in mammal remain controversy.
To investigate the effect of chronic lead exposure on auditory system, 40 adult guinea pigs with normal hearing were randomly divided into five groups.
They were fed 2 mmol/L lead acetate in drinking water for 0, 15, 30, 60, and 90 days (n = 8), respectively.
Lead concentrations in blood, cochlea, and brainstem were measured.
Auditory function was measured by auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE).
The morphology of cochlea and brainstem was observed, and expression of autophagy-related protein in brainstem was also assessed.
The blood lead concentration reached a high level at the 15th day and kept stable, but the lead level in brainstem and cochlear tissue increased obviously at the 60th day and 90th day of lead exposure, respectively.
There was no significant difference in the morphology of hair cells and stria vascularis (SV) among these five groups, but the number of spiral ganglion neuron (SGN) gradually decreased after 60 days.
The differences of ABR thresholds and DPOAE amplitudes were not statistically significant among each group, but I wave latency, III latency, and I-III wave interval of ABR were delayed with the prolonging of time of lead exposure.
The expressions of autophagy-related protein ATG5, ATG6, and LC3B in brainstem were increased after 30 days.
These results suggest that the key target of lead toxicity was the auditory nerve conduction pathway including SGNs and brainstem, rather than cochlear hair cells and SV.
Autophagy may play a very important role in lead toxicity to auditory nervous system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yanni& Jiang, Qian& Xie, Shaobing& Wu, Xuewen& Zhou, Jun& Sun, Hong. 2019. Lead Induced Ototoxicity and Neurotoxicity in Adult Guinea Pig. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1124723
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yanni…[et al.]. Lead Induced Ototoxicity and Neurotoxicity in Adult Guinea Pig. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1124723
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yanni& Jiang, Qian& Xie, Shaobing& Wu, Xuewen& Zhou, Jun& Sun, Hong. Lead Induced Ototoxicity and Neurotoxicity in Adult Guinea Pig. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1124723
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124723
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر