Technical Verification and Assessment of Independent Validation of Biomarker Models for Endometriosis
المؤلفون المشاركون
Fassbender, Amelie
O, Dorien F.
Vanhie, A.
Van Bree, Rita
Laenen, Annouschka
Peterse, Daniëlle P.
Waelkens, Etienne
D’Hooghe, Thomas M.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
There is a great need for a noninvasive diagnosis for endometriosis.
Several biomarkers and biomarker panels have been proposed.
Biomarker models consisting of CA-125, VEGF, Annexin V, and glycodelin/sICAM-1 were previously developed by our group.
The objective of our current study was to assess the impact of technical and biological variability on the performance of those previously developed prediction models in a technical verification and a validation setting.
The technical verification cohort consisted of peripheral blood plasma samples from a subset of the patients included in the original study of Vodolazkaia et al.
(99 women with and 37 women without endometriosis).
The validation study was done in plasma samples of an independent patient cohort (170 women with and 86 women without endometriosis).
Single immunoassays were used for CA-125, VEGF-A, sICAM-1, Annexin V, and glycodelin.
Statistical analyses were done using univariate and multivariate (logistic regression) approaches.
The previously reported prediction models for endometriosis had a low performance in both the technical verification and validation setting.
New prediction models were developed, which included CA-125, Annexin V, and sICAM-1, but CA-125 was the only marker that was retained in the models across the technical verification and validation study.
Overall, successful validation of a biomarker model depends on several factors such as patient selection, collection methods, assay selection/handling, stability of the marker, and statistical analysis and interpretation.
There is a need for standardized studies in large, well-defined patient cohorts with robust assay methodologies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
O, Dorien F.& Fassbender, Amelie& Van Bree, Rita& Laenen, Annouschka& Peterse, Daniëlle P.& Vanhie, A.…[et al.]. 2019. Technical Verification and Assessment of Independent Validation of Biomarker Models for Endometriosis. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1124748
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
O, Dorien F.…[et al.]. Technical Verification and Assessment of Independent Validation of Biomarker Models for Endometriosis. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1124748
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
O, Dorien F.& Fassbender, Amelie& Van Bree, Rita& Laenen, Annouschka& Peterse, Daniëlle P.& Vanhie, A.…[et al.]. Technical Verification and Assessment of Independent Validation of Biomarker Models for Endometriosis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1124748
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124748
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر