Association Study of Myosin Heavy Chain 15 Polymorphisms with Asthma Susceptibility in Chinese Han
المؤلفون المشاركون
Sandford, Andrew
Chen, Guo
Luo, Lan
Zhang, Miao-Miao
Wu, Shou-Quan
Wang, Yu
He, Jian-Qing
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
The Myosin Heavy Chain 15 gene (MYH15) is expressed in the airway epithelium and variants in the gene have been associated with airway responsiveness.
The aim of this study was to perform the first investigation of MYH15 polymorphisms in relation to asthma susceptibility.
Methods.
A total of 410 asthma patients and 418 controls from the Chinese Han population were enrolled in the study.
Tag-single nucleotide polymorphisms were genotyped and associations between the polymorphisms and asthma risk were analyzed by logistic regression analysis adjusting for confounding factors.
Dual-luciferase reporter gene analysis was performed to detect allele-dependent promoter activity of MYH15 variants in HEK293 cells.
Results.
The A allele of rs9288876 decreased risk of asthma (allelic model: OR=0.808, 95% CI: 0.658-0.993, additive model: OR=0.747, 95% CI: 0.588-0.947, dominant model: OR=0.693, 95% CI: 0.502-0.955).
The G alleles of both rs7635009 and rs1454197 were associated with decreased risk of asthma under the additive model (OR=0.779, 95% CI: 0.618-0.981 and OR=0.756, 95% CI: 0.600-0.953, respectively).
rs9288876 allele A was associated with higher luciferase activity than allele T (P<0.001).
The luciferase activity of rs7635009 allele A was lower than allele G (P=0.001), while rs1454197 allele T had lower luciferase activity than allele G (P<0.001).
Conclusion.
This is the first study to report the association of MYH15 gene polymorphisms with asthma.
Polymorphisms of rs9288876, rs7635009, and rs1454197 altered transcriptional regulation of MYH15 and may be functional variants conferring susceptibility to asthma.
Further study with larger sample size in different ethnic populations is needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Guo& Luo, Lan& Zhang, Miao-Miao& Wu, Shou-Quan& Wang, Yu& Sandford, Andrew…[et al.]. 2019. Association Study of Myosin Heavy Chain 15 Polymorphisms with Asthma Susceptibility in Chinese Han. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1124855
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Guo…[et al.]. Association Study of Myosin Heavy Chain 15 Polymorphisms with Asthma Susceptibility in Chinese Han. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1124855
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Guo& Luo, Lan& Zhang, Miao-Miao& Wu, Shou-Quan& Wang, Yu& Sandford, Andrew…[et al.]. Association Study of Myosin Heavy Chain 15 Polymorphisms with Asthma Susceptibility in Chinese Han. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1124855
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124855
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر