![](/images/graphics-bg.png)
Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism
المؤلفون المشاركون
Wang, Xiaobo
Zhao, Dong
Yang, Long-Yan
Yin, Ruili
Wang, Zongwei
Zhang, Yuanyuan
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
Angiopoietin-like proteins (Angptls) play critical roles in biological processes, primarily in lipid metabolism.
The functional state of the thyroid has a profound influence on metabolism in the human body.
Therefore, the aim of this study was to investigate possible changes in serum Angptl3, 4, and 8 levels in hypothyroid patients.
Methods.
The study included 29 patients with clinical hypothyroidism, 30 patients with subclinical hypothyroidism, and 29 healthy subjects.
Baseline clinical indices, including serum thyroid function tests, were recorded and serum Angptl3, 4, and 8 levels were measured across the three groups.
Results.
Serum Angptl3 and 8 levels were significantly higher in the hypothyroid groups compared to the control group (p < 0.05).
There were no differences in Angptl4 levels among the three groups (p > 0.05).
Positive correlations were identified between Angptl3 and high-density lipoprotein cholesterol (r = 0.431, p < 0.001), and there was a negative correlation between Angptl3 and total tri-iodothyronine (TT3) (r = -0.220, p = 0.047) and free tri-iodothyronine (r = - 0.279, p = 0.013) levels.
Angptl8 was positively correlated with triglyceride (r = 0.267, p = 0.012) and cholesterol levels (r= 0.235, p = 0.028) but was negatively correlated with tri-iodothyronine (r = -0.24, p = 0.031).
Furthermore, we used receiver operating characteristic curve analysis to evaluate the diagnostic performance of Angptl3 and 8 in discriminating thyroid dysfunction.
The area under curve for detecting thyroid dysfunction based on Angptl3 and Angptl8 was 0.763.
Conclusions.
Our data show that serum Angptl3 and 8 levels are increased in clinical and subclinical hypothyroid patients and that Angptl3 and 8 may serve as possible biomarkers of hypothyroid disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Long-Yan& Yin, Ruili& Wang, Zongwei& Wang, Xiaobo& Zhang, Yuanyuan& Zhao, Dong. 2019. Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124863
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Long-Yan…[et al.]. Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1124863
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Long-Yan& Yin, Ruili& Wang, Zongwei& Wang, Xiaobo& Zhang, Yuanyuan& Zhao, Dong. Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124863
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124863
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)