Customized Scaffold Design Based on Natural Peripheral Nerve Fascicle Characteristics for Biofabrication in Tissue Regeneration

المؤلفون المشاركون

Yao, Zhi
Yan, Li-Wei
Qiu, Shuai
He, Fu-Lin
Gu, Fan-Bin
Liu, Xiao-Lin
Qi, Jian
Zhu, Qing-Tang

المصدر

BioMed Research International

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-12-14

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Objective.

The use of a biofabrication nerve scaffold, which mimics the nerve microstructure, as an alternative for autologous nerve transplantation is a promising strategy for treating peripheral nerve defects.

This study aimed to design a customized biofabrication scaffold model with the characteristics of human peripheral nerve fascicles.

Methods.

We used Micro-MRI technique to obtain different nerve fascicles.

A full-length 28 cm tibial nerve specimen was obtained and was divided into 14 two-centimetre nerve segments.

3D models of the nerve fascicles were obtained by three-dimensional reconstruction after image segmentation.

The central line of the nerve fascicles was fitted, and the aggregation of nerve fascicles was analysed quantitatively.

The nerve scaffold was designed by simulating the clinical nerve defect and extracting information from the acquired nerve fascicle data; the scaffold design was displayed by 3D printing to verify the accuracy of the model.

Result.

The microstructure of the sciatic nerve, tibial nerve, and common peroneal nerve in the nerve fascicles could be obtained by three-dimensional reconstruction.

The number of cross fusions of tibial nerve fascicles from proximal end to distal end decreased gradually.

By designing the nerve graft in accordance with the microstructure of the nerve fascicles, the 3D printed model demonstrated that the two ends of the nerve defect can be well matched.

Conclusion.

The microstructure of the nerve fascicles is complicated and changeable, and the spatial position of each nerve fascicle and the long segment of the nerve fascicle aggregation show great changes at different levels.

Under the premise of the stability of the existing imaging techniques, a large number of scanning nerve samples can be used to set up a three-dimensional database of the peripheral nerve fascicle microstructure, integrating the gross imaging information, and provide a template for the design of the downstream nerve graft model.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yao, Zhi& Yan, Li-Wei& Qiu, Shuai& He, Fu-Lin& Gu, Fan-Bin& Liu, Xiao-Lin…[et al.]. 2019. Customized Scaffold Design Based on Natural Peripheral Nerve Fascicle Characteristics for Biofabrication in Tissue Regeneration. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1124878

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yao, Zhi…[et al.]. Customized Scaffold Design Based on Natural Peripheral Nerve Fascicle Characteristics for Biofabrication in Tissue Regeneration. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1124878

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yao, Zhi& Yan, Li-Wei& Qiu, Shuai& He, Fu-Lin& Gu, Fan-Bin& Liu, Xiao-Lin…[et al.]. Customized Scaffold Design Based on Natural Peripheral Nerve Fascicle Characteristics for Biofabrication in Tissue Regeneration. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1124878

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1124878