Activated Macrophages of Monocytic Origin Predominantly Express Proinflammatory Cytokine Genes, Whereas Kupffer Cells Predominantly Express Anti-Inflammatory Cytokine Genes
المؤلفون المشاركون
Fatkhudinov, Timur
Bolshakova, Galina
Arutyunyan, Irina
Glinkina, Valeria
Goldshtein, Dmitry
Sukhikh, Gennady
Elchaninov, Andrey
Makarov, Andrey
Lokhonina, Anastasia
Grinberg, Maria
Surovtsev, Viktor
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-05
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
In the central nervous system and in the liver, the macrophage populations are represented exclusively by descendants of the hematopoietic progenitor cells of the yolk sac.
The reasons for such differential distribution of macrophages are not fully understood.
We found that, as can be judged by corresponding changes in the expression of CD86 and CD163 markers, the transient macrophages of monocytic lineage are more sensitive to activating stimuli.
The two macrophage populations have distinct patterns of gene expression, which is particularly noticeable for M1- and M2-associated genes.
For instance, Kupffer cells more readily develop and longer maintain the elevated expression levels of Il4, Il10, and Il13 upon the activation; by contrast, the macrophages of monocytic lineage express Il1b, Il12a, and Tnfα upon the activation.
The obtained results allow us to conclude that the in vitro activated Kupffer cells of the liver are committed to M2 phenotype, whereas the in vitro activated monocyte-derived macrophages show a typical M1 behavior.
These observations are likely to reflect the situation in the in vivo microenvironments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lokhonina, Anastasia& Elchaninov, Andrey& Fatkhudinov, Timur& Makarov, Andrey& Arutyunyan, Irina& Grinberg, Maria…[et al.]. 2019. Activated Macrophages of Monocytic Origin Predominantly Express Proinflammatory Cytokine Genes, Whereas Kupffer Cells Predominantly Express Anti-Inflammatory Cytokine Genes. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1124958
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lokhonina, Anastasia…[et al.]. Activated Macrophages of Monocytic Origin Predominantly Express Proinflammatory Cytokine Genes, Whereas Kupffer Cells Predominantly Express Anti-Inflammatory Cytokine Genes. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1124958
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lokhonina, Anastasia& Elchaninov, Andrey& Fatkhudinov, Timur& Makarov, Andrey& Arutyunyan, Irina& Grinberg, Maria…[et al.]. Activated Macrophages of Monocytic Origin Predominantly Express Proinflammatory Cytokine Genes, Whereas Kupffer Cells Predominantly Express Anti-Inflammatory Cytokine Genes. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1124958
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124958
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر