Identification of Gastric Cancer-Related Circular RNA through Microarray Analysis and Bioinformatics Analysis
المؤلفون المشاركون
Gu, Wei
Sun, Ying
Zheng, Xiong
Ma, Jin
Hu, Xiao-Ying
Gao, Tian
Hu, Mei-Jie
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Gastric cancer is one of the common malignant tumors worldwide.
Increasing studies have indicated that circular RNAs (circRNAs) play critical roles in the cancer progression and have shown great potential as useful markers and therapeutic targets.
However, the precise mechanism and functions of most circRNAs are still unknown in gastric cancer.
In the present study, we performed a microarray analysis to detect circRNA expression changes between tumor samples and adjacent nontumor samples.
The miRNA expression profiles were obtained from the National Center of Biotechnology Information Gene Expression Omnibus (GEO).
The differentially expressed circRNAs and miRNAs were identified through fold change filtering.
The interactions between circRNAs and miRNAs were predicted by Arraystar’s home-made miRNA target prediction software.
After circRNA-related miRNAs and dysregulated miRNAs were intersected, 23 miRNAs were selected.
The target mRNAs of miRNAs were predicted by TarBase v7.0.
Gene ontology (GO) enrichment analysis and pathway analysis were performed using standard enrichment computational methods for the target mRNAs.
The results of pathway analysis showed that p53 signaling pathway and hippo signal pathway were significantly enriched and CCND2 was a cross-talk gene associated with them.
Finally, a circRNA-miRNA-mRNA regulation network was constructed based on the gene expression profiles and bioinformatics analysis results to identify hub genes and hsa_circRNA_101504 played a central role in the network.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gu, Wei& Sun, Ying& Zheng, Xiong& Ma, Jin& Hu, Xiao-Ying& Gao, Tian…[et al.]. 2018. Identification of Gastric Cancer-Related Circular RNA through Microarray Analysis and Bioinformatics Analysis. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125016
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gu, Wei…[et al.]. Identification of Gastric Cancer-Related Circular RNA through Microarray Analysis and Bioinformatics Analysis. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1125016
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gu, Wei& Sun, Ying& Zheng, Xiong& Ma, Jin& Hu, Xiao-Ying& Gao, Tian…[et al.]. Identification of Gastric Cancer-Related Circular RNA through Microarray Analysis and Bioinformatics Analysis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125016
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125016
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر