Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy
المؤلفون المشاركون
Kazda, Tomas
Slampa, Pavel
Jancalek, Radim
Misove, Adela
Burkon, Petr
Pospisil, Petr
Hynkova, Ludmila
Selingerova, Iveta
Dziacky, Adam
Belanova, Renata
Bulik, Martin
Rehak, Zdenek
Slama, Ondrej
Slaby, Ondrej
Lakomy, Radek
Poprach, Alexandr
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Hippocampi sparing whole brain radiotherapy (WBRT) is an evolving approach in the treatment of patients with multiple brain metastases, pursuing mitigation of verbal memory decline as a consequence of hippocampal radiation injury.
Accumulating data are showing different postradiotherapy changes in the left and right hippocampus with a theoretical proposal of only unilateral (dominant, left) hippocampal sparing during WBRT.
Method.
The aim of this retrospective study is to describe spatial distribution of brain metastases on MRI in a cohort of 260 patients (2595 metastases) and to evaluate distribution separately in the left and right hippocampus and in respective hippocampal avoiding zones (HAZ, region with subtherapeutic radiation dose), including evaluation of location of metastatic mass centre.
Results.
The median number of brain metastases was three, with lung cancer being the most common type of primary tumour; 36% had single metastasis.
Almost 8% of patients had metastasis within hippocampus (1.1% of all metastases) and 18.1% of patients within HAZ (3.3% of all metastases).
No statistically significant difference was observed in the laterality of hippocampal involvement, also when the location of centre of metastases was analyzed.
There were more patients presenting the centre of metastasis within left (15) versus right (6) HAZ approaching the borderline of statistical significance.
Conclusion.
No significant difference in the laterality of BM seeding within hippocampal structures was observed.
The hypothesized unilateral sparing WBRT would have theoretical advantage in about 50% reduction in the risk of subsequent recurrence within spared regions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kazda, Tomas& Misove, Adela& Burkon, Petr& Pospisil, Petr& Hynkova, Ludmila& Selingerova, Iveta…[et al.]. 2018. Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1125061
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kazda, Tomas…[et al.]. Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1125061
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kazda, Tomas& Misove, Adela& Burkon, Petr& Pospisil, Petr& Hynkova, Ludmila& Selingerova, Iveta…[et al.]. Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1125061
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125061
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر