NFIL3 Acts as a Nuclear Factor to Increase Osteosarcoma Progression

المؤلفون المشاركون

Xu, Jiaxing
Xu, Gongping
Zhang, Tingxin
Chen, Tiantian
Zhao, Wei
Wang, Guangyou

المصدر

BioMed Research International

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-11-30

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Purpose.

Osteosarcoma is one of the most common primary malignant, aggressive bone neoplasms.

However, the mechanisms of osteosarcoma proliferation, migration, and invasion are not well understood.

To explore the possible mechanism of osteosarcoma progression, we used a public database for gene analysis to identify the possible factors that are important in osteosarcoma progression.

Nuclear factor interleukin 3 (NFIL3) regulated was highly expressed in sarcoma tissues.

In this study, we meant to probe the function of NFIL3 in osteosarcoma proliferation, migration, and invasion.

Methods.

The expression of NFIL3 in osteosarcoma tissues was analysed via RT-PCR and immunohistochemistry staining.

In order to elucidate the function of NFIL3 in osteosarcoma, we performed cell growth assays and colony formation assays to explore the role of NFIL3 in proliferation in osteosarcoma cells.

Futhermore, we analysed osteosarcoma cell migration and invasion via wound healing assays and transwell migration and invasion assays.

Results.

NFIL3 is overexpressed in osteosarcoma tissues; 15 of the 20 osteosarcoma tissues analysed highly expressed NFIL3.

Our in vitro experiments confirmed that NFIL3 promoted the proliferation of M6-63 and SaOS2 cells (P<0.01).

In addition, NFIL3 promoted the migration and invasion of osteosarcoma cells (P<0.05).

Conclusion.

NFIL3 is highly expressed in osteosarcoma tissues and thus promotes the proliferation, migration, and invasion of osteosarcoma cells.

NFIL3 is potential to become a new target for development of novel treatment strategies of osteosarcoma.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xu, Jiaxing& Xu, Gongping& Zhang, Tingxin& Chen, Tiantian& Zhao, Wei& Wang, Guangyou. 2019. NFIL3 Acts as a Nuclear Factor to Increase Osteosarcoma Progression. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125091

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xu, Jiaxing…[et al.]. NFIL3 Acts as a Nuclear Factor to Increase Osteosarcoma Progression. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1125091

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xu, Jiaxing& Xu, Gongping& Zhang, Tingxin& Chen, Tiantian& Zhao, Wei& Wang, Guangyou. NFIL3 Acts as a Nuclear Factor to Increase Osteosarcoma Progression. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125091

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1125091