Involvement of Cholinergic Dysfunction and Oxidative Damage in the Effects of Simulated Weightlessness on Learning and Memory in Rats
المؤلفون المشاركون
Liu, Xin-Min
Li, Yinghui
Zhang, Yongliang
Wang, Qiong
Chen, Hailong
Lv, Ke
Wang, Tingmei
Wang, Yanli
Ji, Guohua
Cao, Hongqing
Kan, Guanghan
Qu, Lina
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The present study aimed to determine how the learning and memory gradually change with the prolonged hindlimb unloading (HU) treatment in rats.
Different HU durations (7 d, 14 d, 21 d, and 28 d) in Sprague-Dawley (SD) rats were implemented.
Cognitive function was assessed using the Morris water maze (MWM) and the shuttle box test.
Additionally, parameters about cholinergic activity and oxidative stress were tested.
Results showed that longer-than-14 d HU led to the inferior performances in the behavioral tasks.
Besides, acetylcholine esterase (AChE) activity, malondialdehyde (MDA) level in brain, reactive oxygen species (ROS), and 8-hydroxy-2-deoxyguanosine (8-OHdG) concentrations of HU rats were significantly increased.
Furthermore, choline acetyltransferase (ChAT), superoxide dismutase (SOD), and catalase (CAT) activity in brain were notably attenuated.
Most of these effects were more pronounced after longer exposure (21 d and 28 d) to HU, although some indicators had their own characteristics of change.
These results indicate that cholinergic dysfunction and oxidative damage were involved in the learning and memory impairments induced by longer-than-14 d HU.
Moreover, the negative effects of HU tend to be augmented as the HU duration becomes longer.
The results may be helpful to present possible biochemical targets for countermeasures development regarding the memory deficits under extreme environmental conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yongliang& Wang, Qiong& Chen, Hailong& Liu, Xin-Min& Lv, Ke& Wang, Tingmei…[et al.]. 2018. Involvement of Cholinergic Dysfunction and Oxidative Damage in the Effects of Simulated Weightlessness on Learning and Memory in Rats. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1125105
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yongliang…[et al.]. Involvement of Cholinergic Dysfunction and Oxidative Damage in the Effects of Simulated Weightlessness on Learning and Memory in Rats. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1125105
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yongliang& Wang, Qiong& Chen, Hailong& Liu, Xin-Min& Lv, Ke& Wang, Tingmei…[et al.]. Involvement of Cholinergic Dysfunction and Oxidative Damage in the Effects of Simulated Weightlessness on Learning and Memory in Rats. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1125105
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125105
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر