Role of TGF-Beta1SMAD23 Pathway in Retinal Outer Deep Vascular Plexus and Photoreceptor Damage in Rat 5010 Oxygen-Induced Retinopathy
المؤلفون المشاركون
Li, Huijuan
Zhu, Ruyuan
Zhao, Ruibin
Qian, Lijuan
Jiang, Li
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
In retinopathy of prematurity (ROP), outer deep vascular plexus (oDVP) was the emerging field, and the mechanisms of photoreceptor dysfunction remained to be explored.
ODVP and photoreceptors were related, with oDVP being part of the supplier of oxygen and nutrients to photoreceptors, while their possible relationship in ROP was not clear.
TGF-beta1 has been reported indispensable in oDVP development and altered in ROP patients and animal models.
We hypothesized that the TGF-beta1 alteration in rat 50/10 oxygen-induced retinopathy (OIR) model contributed to oDVP malformation and exerted consequent effects on photoreceptor development.
We first explored the profile of oDVP development in rat after birth and compared the expression of TGF-beta1 and pSMAD2/3 in Normoxia and OIR groups.
Afterwards, the inhibitor of the pathway, LY364947, was used to establish the OIR, OIR+LY364947, Normoxia, and Normoxia+LY364947 groups.
The oDVP and photoreceptor were examined by Isolectin B4 staining, western-blot of CD31 and Rho, and electron microscopy.
ODVP sprouted at postnatal day 10 (D10) and reached the edge of retina at D14.
The TGF-beta1/SMAD2/3 pathway was compromised during the critical period of oDVP development.
The inhibitor simulated the oDVP retardation, pericyte, and photoreceptor malformation in the Normoxia+LY364947 group and might further compromise the development of oDVP and photoreceptor in the OIR+LY364947 group.
The inhibition of the TGF-beta1/SMAD2/3 pathway indicated its critical role in oDVP malformation and photoreceptor damage, suggesting a possible therapeutic target of ROP treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Huijuan& Zhu, Ruyuan& Zhao, Ruibin& Qian, Lijuan& Jiang, Li. 2019. Role of TGF-Beta1SMAD23 Pathway in Retinal Outer Deep Vascular Plexus and Photoreceptor Damage in Rat 5010 Oxygen-Induced Retinopathy. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1125109
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Huijuan…[et al.]. Role of TGF-Beta1SMAD23 Pathway in Retinal Outer Deep Vascular Plexus and Photoreceptor Damage in Rat 5010 Oxygen-Induced Retinopathy. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1125109
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Huijuan& Zhu, Ruyuan& Zhao, Ruibin& Qian, Lijuan& Jiang, Li. Role of TGF-Beta1SMAD23 Pathway in Retinal Outer Deep Vascular Plexus and Photoreceptor Damage in Rat 5010 Oxygen-Induced Retinopathy. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1125109
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125109
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر