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Quantitative Proteomic Analyses of a Pathogenic Strain and Its Highly Passaged Attenuated Strain of Mycoplasma hyopneumoniae
المؤلفون المشاركون
Fang, Liurong
Wang, Dang
Xiao, Shaobo
Li, Sha
Liu, Wei
Song, Tao
Zhao, Fuwei
Zhang, Ruoxi
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-01
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Mycoplasma hyopneumoniae is the causative agent of porcine enzootic pneumonia, a chronic respiratory disease in swine resulting in enormous economic losses.
To identify the components that contribute to virulence and unveil those biological processes potentially related to attenuation, we used isobaric tags for relative and absolute quantification technology (iTRAQ) to compare the protein profiles of the virulent M.
hyopneumoniae strain 168 and its attenuated highly passaged strain 168L.
We identified 489 proteins in total, 70 of which showing significant differences in level of expression between the two strains.
Remarkably, proteins participating in inositol phosphate metabolism were significantly downregulated in the virulent strain, while some proteins involved in nucleoside metabolism were upregulated.
We also mined a series of novel promising virulence-associated factors in our study compared with those in previous reports, such as some moonlighting adhesins, transporters, lipoate-protein ligase, and ribonuclease and several hypothetical proteins with conserved functional domains, deserving further research.
Our survey constitutes an iTRAQ-based comparative proteomic analysis of a virulent M.
hyopneumoniae strain and its attenuated strain originating from a single parent with a well-characterized genetic background and lays the groundwork for future work to mine for potential virulence factors and identify candidate vaccine proteins.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Sha& Fang, Liurong& Liu, Wei& Song, Tao& Zhao, Fuwei& Zhang, Ruoxi…[et al.]. 2019. Quantitative Proteomic Analyses of a Pathogenic Strain and Its Highly Passaged Attenuated Strain of Mycoplasma hyopneumoniae. BioMed Research International،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1125170
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Sha…[et al.]. Quantitative Proteomic Analyses of a Pathogenic Strain and Its Highly Passaged Attenuated Strain of Mycoplasma hyopneumoniae. BioMed Research International No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1125170
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Sha& Fang, Liurong& Liu, Wei& Song, Tao& Zhao, Fuwei& Zhang, Ruoxi…[et al.]. Quantitative Proteomic Analyses of a Pathogenic Strain and Its Highly Passaged Attenuated Strain of Mycoplasma hyopneumoniae. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1125170
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125170
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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