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Efficacy and Tolerability of Intravenous Ferric Carboxymaltose in Patients with Iron Deficiency at a Hospital Outpatient Clinic: A Retrospective Cohort Study of Real-World Clinical Practice
المؤلفون المشاركون
Rocha, Sara Lemos
Robalo Nunes, António
Palricas Costa, Ana
Garcia de Oliveira, Ana
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Ferric carboxymaltose (FCM) is an intravenous iron formulation to correct iron deficiency.
Although its use has been extensively studied in clinical trials, real-world evidence regarding FCM treatment is scarce.
Our aim was to evaluate the efficacy and tolerability of FCM treatment in patients with iron deficiency, with or without anemia, at a hospital outpatient clinic.
Data was collected retrospectively from medical records.
During this 2-year study, 459 patients were included.
Mean age was 58.6 ± 17.5 years and most patients received cumulative FCM doses of 501–1000 mg (63.2%).
Six weeks after administration of FCM, efficacy endpoints hemoglobin increase ≥2 g/dL, hemoglobin increase ≥3 g/dL, and transferrin saturation > 20% were attained by 41%, 20%, and 63% of patients, respectively.
Patients who received higher FCM doses showed significant reduced odds of not achieving hemoglobin increase ≥2 g/dL (501–1000 mg, adjusted odds ratio [OR]: 0.34, 95% confidence interval [CI] 0.18–0.62; 1001–3000 mg, OR: 0.19, 95% CI 0.07–0.49), compared to 500 mg doses.
Treatment-emergent adverse events were documented in <4% of patients.
In conclusion, FCM treatment was effective and well-tolerated by outpatients with iron deficiency at a hospital clinic, and its dosage should be adjusted to improve iron deficiency management in clinical practice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Robalo Nunes, António& Palricas Costa, Ana& Rocha, Sara Lemos& Garcia de Oliveira, Ana. 2017. Efficacy and Tolerability of Intravenous Ferric Carboxymaltose in Patients with Iron Deficiency at a Hospital Outpatient Clinic: A Retrospective Cohort Study of Real-World Clinical Practice. Anemia،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1125194
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Robalo Nunes, António…[et al.]. Efficacy and Tolerability of Intravenous Ferric Carboxymaltose in Patients with Iron Deficiency at a Hospital Outpatient Clinic: A Retrospective Cohort Study of Real-World Clinical Practice. Anemia No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1125194
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Robalo Nunes, António& Palricas Costa, Ana& Rocha, Sara Lemos& Garcia de Oliveira, Ana. Efficacy and Tolerability of Intravenous Ferric Carboxymaltose in Patients with Iron Deficiency at a Hospital Outpatient Clinic: A Retrospective Cohort Study of Real-World Clinical Practice. Anemia. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1125194
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125194
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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