Hypoxia Imaging and Biological Evaluation of the Radiosensitizing Effect of Oleanolic Acid
المؤلفون المشاركون
Wang, Hui
Zhang, Yu
Yu, Wenjing
Xue, Yangyang
Xiao, Liang
Xu, Huiqin
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background and Purpose.
The aim of this study was to evaluate the radiosensitizing effect of oleanolic acid (OA) on C6 rat glioma and the changes in tumor biology during radiosensitization therapy on 18F-fluoromisonidazole (18F-FMISO) positron emission tomography/computed tomography (PET/CT).
Methods.
The radiosensitizing effect of OA on C6 tumors was assessed in vivo by measuring the tumor inhibitory rate and rat survival time.
Meanwhile, rats with C6 tumors were imaged with 18F-FMISO PET/CT during radiosensitization therapy.
Tumor-to-muscle ratio (TMR) of 18F-FMISO maximum uptake was calculated by region of interest analysis.
Changes in tumor biology after therapy were assessed with immunohistochemical staining.
18F-FMISO uptake was analyzed in relation to expression of tumor biomarkers including hypoxia-inducible factor (HIF)-1α, glucose transporter (Glut-1), the proliferation antigen Ki67, tumor suppressor P53, and microvessel density (MVD).
Results.
The results showed that OA combined with radiation inhibited the growth rates of tumors and prolonged the survival period of tumor-bearing rats effectively (χ2 = 12.5, p < 0.01).
18F-FMISO PET/CT indicated decreases in hypoxia after radiosensitization therapy.
Statistical differences were observed in TMR of the irradiation group and OA combined with irradiation group (t = 3.32, p < 0.05).
HIF-1α, Glut-1, Ki67, P53, and MVD expressions in tumors were downregulated by OA combined with radiation as well as with radiation alone.
Additionally, there was a significant positive linear correlation between TMR and HIF-1α, Glut-1, Ki67, P53, and MVD.
Conclusions.
These results suggest that OA has a radiosensitizing effect on C6 tumors in terms of tumor volume inhibition, survival extension, and multiple poor prognosis biological markers downregulation.
18F-FMISO PET/CT can be of value for tumor biology noninvasive capture and radiosensitization response evaluation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Hui& Zhang, Yu& Yu, Wenjing& Xue, Yangyang& Xiao, Liang& Xu, Huiqin. 2018. Hypoxia Imaging and Biological Evaluation of the Radiosensitizing Effect of Oleanolic Acid. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125236
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Hui…[et al.]. Hypoxia Imaging and Biological Evaluation of the Radiosensitizing Effect of Oleanolic Acid. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1125236
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Hui& Zhang, Yu& Yu, Wenjing& Xue, Yangyang& Xiao, Liang& Xu, Huiqin. Hypoxia Imaging and Biological Evaluation of the Radiosensitizing Effect of Oleanolic Acid. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125236
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125236
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر