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Curcumin Induces Neural Differentiation of Human Pluripotent Embryonal Carcinoma Cells through the Activation of Autophagy
المؤلفون المشاركون
Heebkaew, Nudjanad
Rujanapun, Narawadee
Kunhorm, Phongsakorn
Jaroonwitchawan, Thiranut
Chaicharoenaudomrung, Nipha
Promjantuek, Wilasinee
Noisa, Parinya
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-21
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Curcumin is a natural polyphenolic compound, isolated from Curcuma longa, and is an important ingredient of Asian foods.
Curcumin has revealed its strong activities of anti-inflammatory, antioxidant, and anticancer.
The efficient amount of curcumin could induce differentiation of stem cells and promoted the differentiation of glioma-initiating cells; however, the mechanisms underlying neural induction of curcumin have not yet been revealed.
In this study, neural-inducing ability of curcumin was explored by using human pluripotent embryonal carcinoma cells, NTERA2 cells.
The cells were induced toward neural lineage with curcumin and were compared with a standard neutralizing agent (retinoic acid).
It was found that, after 14 days of the induction by curcumin, NTERA2 cells showed neuronal morphology and expressed neural-specific genes, including NeuroD, TUJ1, and PAX6.
Importantly, curcumin activated neurogenesis of NTERA2 cells via the activation of autophagy, since autophagy-related genes, such as LC3, LAMP1, and ATG5, were upregulated along with the expression of neural genes.
The inhibition of autophagy by chloroquine suppressed both autophagy and neural differentiation, highlighting the positive role of autophagy during neural differentiation.
This autophagy-mediated neural differentiation of curcumin was found to be an ROS-dependent manner; curcumin induced ROS generation and suppressed antioxidant gene expression.
Altogether, this study proposed the neural-inducing activity of curcumin via the regulation of autophagy within NTERA2 cells and underscored the health beneficial effects of curcumin for neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Heebkaew, Nudjanad& Rujanapun, Narawadee& Kunhorm, Phongsakorn& Jaroonwitchawan, Thiranut& Chaicharoenaudomrung, Nipha& Promjantuek, Wilasinee…[et al.]. 2019. Curcumin Induces Neural Differentiation of Human Pluripotent Embryonal Carcinoma Cells through the Activation of Autophagy. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1125330
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Heebkaew, Nudjanad…[et al.]. Curcumin Induces Neural Differentiation of Human Pluripotent Embryonal Carcinoma Cells through the Activation of Autophagy. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1125330
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Heebkaew, Nudjanad& Rujanapun, Narawadee& Kunhorm, Phongsakorn& Jaroonwitchawan, Thiranut& Chaicharoenaudomrung, Nipha& Promjantuek, Wilasinee…[et al.]. Curcumin Induces Neural Differentiation of Human Pluripotent Embryonal Carcinoma Cells through the Activation of Autophagy. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1125330
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125330
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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