Ubenimex Reverses MDR in Gastric Cancer Cells by Activating Caspase-3-Mediated Apoptosis and Suppressing the Expression of Membrane Transport Proteins
المؤلفون المشاركون
Guo, Qie
Jing, Fan-jing
Qu, Hai-jun
Xu, Wen
Han, Bing
Xing, Xiao-min
Ji, Hong-yan
Jing, Fan-Bo
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-20
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Gastric cancer (GC) is one of the most malignant tumors, accounting for 10% of deaths caused by all cancers.
Chemotherapy is often necessary for treatment of GC; the FOLFOX regimen is extensively applied.
However, multidrug resistance (MDR) of GC cells prevents wider application of this treatment.
Ubenimex, an inhibitor of CD13, is used as an immune adjuvant to treat hematological malignancies.
Here, we demonstrate that CD13 expression positively correlates with MDR development in GC cells.
Moreover, Ubenimex reverses the MDR of SGC7901/X and MKN45/X cells and enhances their sensitivity to FOLFOX, in part by decreasing CD13 expression, which is accompanied by downregulation of Bcl-xl, Bcl-2, and survivin expression; increased expression of Bax; and activation of the caspase-3-mediated apoptotic cascade.
In addition, Ubenimex downregulates expression of membrane transport proteins, such as P-gp and MRP1, by inhibiting phosphorylation in the PI3K/AKT/mTOR pathway to increase intracellular accumulations of 5-fluorouracil and oxaliplatin, a process for which downregulation of CD13 expression is essential.
Therefore, the present results reveal a previously uncharacterized function of CD13 in promoting MDR development in GC cells and suggest that Ubenimex is a candidate for reversing the MDR of GC cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Qie& Jing, Fan-jing& Qu, Hai-jun& Xu, Wen& Han, Bing& Xing, Xiao-min…[et al.]. 2019. Ubenimex Reverses MDR in Gastric Cancer Cells by Activating Caspase-3-Mediated Apoptosis and Suppressing the Expression of Membrane Transport Proteins. BioMed Research International،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1125346
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Qie…[et al.]. Ubenimex Reverses MDR in Gastric Cancer Cells by Activating Caspase-3-Mediated Apoptosis and Suppressing the Expression of Membrane Transport Proteins. BioMed Research International No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1125346
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Qie& Jing, Fan-jing& Qu, Hai-jun& Xu, Wen& Han, Bing& Xing, Xiao-min…[et al.]. Ubenimex Reverses MDR in Gastric Cancer Cells by Activating Caspase-3-Mediated Apoptosis and Suppressing the Expression of Membrane Transport Proteins. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1125346
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125346
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر