Downregulation of Thromboxane A2 Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery
المؤلفون المشاركون
Zhang, Yaping
Mi, Man
Xie, Yan-Hua
Wang, Si-Wang
Edvinsson, Lars
Xu, Cang-Bao
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Thromboxane A2 (TXA2) acts on TXA2 receptors (TP) to regulate renal artery blood flow and subsequently contributes to the pathogenesis of renal ischemia.
The present study was designed to examine if nuclear factor-kappaB (NF-κB) signaling pathway is involved in the downregulation of TP receptors in rat renal artery.
Rat renal artery segments were organ cultured for 6 or 24 h.
Downregulation of TP receptors was monitored using myograph (contractile function), real-time PCR (receptor mRNA), and immunohistochemistry (receptor protein).
Specific inhibitors (MG-132 and BMS345541) for NF-κB signaling pathway were used to dissect the underlying molecular mechanisms involved.
Compared to fresh (noncultured) segments, organ culture of the renal artery segments for 24 h induced a significant rightward shift of U46619 (TP receptor agonist) contractile response curves (pEC50: 6.89±0.06 versus 6.48±0.04, P<0.001).
This decreased contractile response to U46619 was paralleled with decreased TP receptor mRNA and protein expressions in the renal artery smooth muscle cells.
Specific inhibitors (MG-132 and BMS345541) for NF-κB signaling pathway significantly abolished the decreased TP protein expression and receptor-mediated contractions.
In conclusion, downregulation of TP receptors in the renal artery smooth muscle cells occurs mainly via the NF-κB signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yaping& Mi, Man& Xie, Yan-Hua& Wang, Si-Wang& Edvinsson, Lars& Xu, Cang-Bao. 2017. Downregulation of Thromboxane A2 Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1125427
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yaping…[et al.]. Downregulation of Thromboxane A2 Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery. Advances in Pharmacological and Pharmaceutical Sciences No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1125427
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yaping& Mi, Man& Xie, Yan-Hua& Wang, Si-Wang& Edvinsson, Lars& Xu, Cang-Bao. Downregulation of Thromboxane A2 Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery. Advances in Pharmacological and Pharmaceutical Sciences. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1125427
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125427
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر