Efficacy of rhBMP-2 Loaded PCLβ-TCPbdECM Scaffold Fabricated by 3D Printing Technology on Bone Regeneration
المؤلفون المشاركون
Kang, Seong Soo
Huh, Jung-Bo
Chung, Ho Yun
Bae, Eun-Bin
Park, Keun-Ho
Shim, Jin-Hyung
Choi, Jae-Won
Lee, Jin-Ju
Kim, Chang-Hwan
Jeon, Ho-Jun
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
This study was undertaken to evaluate the effect of 3D printed polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) scaffold containing bone demineralized and decellularized extracellular matrix (bdECM) and human recombinant bone morphogenetic protein-2 (rhBMP-2) on bone regeneration.
Scaffolds were divided into PCL/β-TCP, PCL/β-TCP/bdECM, and PCL/β-TCP/bdECM/BMP groups.
In vitro release kinetics of rhBMP-2 were determined with respect to cell proliferation and osteogenic differentiation.
These three reconstructive materials were implanted into 8 mm diameter calvarial bone defect in male Sprague-Dawley rats.
Animals were sacrificed four weeks after implantation for micro-CT, histologic, and histomorphometric analyses.
The findings obtained were used to calculate new bone volumes (mm3) and new bone areas (%).
Excellent cell bioactivity was observed in the PCL/β-TCP/bdECM and PCL/β-TCP/bdECM/BMP groups, and new bone volume and area were significantly higher in the PCL/β-TCP/bdECM/BMP group than in the other groups ( p < .
05 ).
Within the limitations of this study, bdECM printed PCL/β-TCP scaffolds can reproduce microenvironment for cells and promote adhering and proliferating the cells onto scaffolds.
Furthermore, in the rat calvarial defect model, the scaffold which printed rhBMP-2 loaded bdECM stably carries rhBMP-2 and enhances bone regeneration confirming the possibility of bdECM as rhBMP-2 carrier.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bae, Eun-Bin& Park, Keun-Ho& Shim, Jin-Hyung& Chung, Ho Yun& Choi, Jae-Won& Lee, Jin-Ju…[et al.]. 2018. Efficacy of rhBMP-2 Loaded PCLβ-TCPbdECM Scaffold Fabricated by 3D Printing Technology on Bone Regeneration. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1125466
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bae, Eun-Bin…[et al.]. Efficacy of rhBMP-2 Loaded PCLβ-TCPbdECM Scaffold Fabricated by 3D Printing Technology on Bone Regeneration. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1125466
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bae, Eun-Bin& Park, Keun-Ho& Shim, Jin-Hyung& Chung, Ho Yun& Choi, Jae-Won& Lee, Jin-Ju…[et al.]. Efficacy of rhBMP-2 Loaded PCLβ-TCPbdECM Scaffold Fabricated by 3D Printing Technology on Bone Regeneration. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1125466
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125466
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر