Hepatitis C Virus-Infected Responders and Relapsers to Treatment Show Similar Genetic Profiles of IL28B and IL10 Single Nucleotide Polymorphisms
المؤلفون المشاركون
Souza, Suiane Lima de
Vidal, Luãnna Liebscher
Ramos, Juliene
Cardoso, Cynthia Chester
Coelho, Henrique Sérgio Moraes
Villela-Nogueira, Cristiane Alves
Perez, Renata de Mello
Santos, André Felipe
Soares, Marcelo A.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Genotype 1 of hepatitis C virus (HCV) is the most prevalent worldwide.
Pegylated-interferon and ribavirin therapy is still used in the developing world but has less efficiency in this genotype.
Single nucleotide polymorphisms (SNPs) rs12979860 and rs8099917 (IL28B) and rs1800896, rs1800871, and rs1800872 (IL10) are related to treatment outcome, but previous studies clustered nonresponse and relapse patients.
The aim of this study is to analyze the frequency of those SNPs in HCV genotype 1 for response, nonresponse, or relapse.
Patients were classified according to treatment outcome.
Genomic DNA was extracted by blood samples and SNPs were defined by PCR and sequencing.
Data analysis was performed with R project.
The frequency of rs12979860 CC was similar among responders (0.48) and relapsers (0.46) and lower among nonresponders (0.18).
The same trend was observed for rs8099917 TT.
rs12979860 CC showed a protective effect for relapsers compared to nonresponders (OR = 0.25) as it occurs with responders (OR = 0.17).
Haplotypes 12979860/C rs8099917/T were associated with protection against the nonresponder phenotype compared to responders (OR = 0.27) or relapsers (OR = 0.37).
Frequency of rs12979860 and rs8099917 is different between relapsers and nonresponders, but similar between relapsers and responders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Souza, Suiane Lima de& Vidal, Luãnna Liebscher& Ramos, Juliene& Cardoso, Cynthia Chester& Coelho, Henrique Sérgio Moraes& Villela-Nogueira, Cristiane Alves…[et al.]. 2018. Hepatitis C Virus-Infected Responders and Relapsers to Treatment Show Similar Genetic Profiles of IL28B and IL10 Single Nucleotide Polymorphisms. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1125524
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Souza, Suiane Lima de…[et al.]. Hepatitis C Virus-Infected Responders and Relapsers to Treatment Show Similar Genetic Profiles of IL28B and IL10 Single Nucleotide Polymorphisms. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1125524
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Souza, Suiane Lima de& Vidal, Luãnna Liebscher& Ramos, Juliene& Cardoso, Cynthia Chester& Coelho, Henrique Sérgio Moraes& Villela-Nogueira, Cristiane Alves…[et al.]. Hepatitis C Virus-Infected Responders and Relapsers to Treatment Show Similar Genetic Profiles of IL28B and IL10 Single Nucleotide Polymorphisms. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1125524
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125524
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر