Interleukin-6 and Interleukin-15 as Possible Biomarkers of the Risk of Autoimmune Diabetes Development
المؤلفون المشاركون
Lipinska, Danuta
Milewski, Robert
Popławska-Kita, Anna
Szelachowska, Małgorzata
Wawrusewicz-Kurylonek, Natalia
Siewko, Katarzyna
Maciulewski, Rafal
Zielinska-Maciulewska, Anna
Szumowski, Piotr
Górska, Maria
Kretowski, Adam
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
The aim of our study was to assay circulating interleukin-15 (IL-15) and interleukin-6 (IL-6) levels and insulin resistance measured by two different methods in newly diagnosed autoimmune diabetes (AD) patients, their I° relatives, and healthy controls.
Material and Methods.
The group studied consisted of 54 patients with AD (28 with Latent Autoimmune Diabetes in Adults (LADA) and 26 with type 1 diabetes (T1D)), 70 first-degree relatives, and 60 controls.
IL-6, IL-15, and anti-islet antibodies concentrations were measured by ELISA method.
Homeostatic model assessment-insulin resistance (HOMAIR) and estimated glucose disposal rate (eGDR) were calculated.
Results.
The patients with AD had significantly higher IL-15, IL-6, and HOMAIR and lower eGDR than the controls (p<0.001, respectively) and first-degree relatives (p<0.001, respectively).
Significantly higher IL-15 and IL-6 were shown in the relatives with positive Ab as compared to the relatives without antibodies (p<0.001, respectively) and the controls (p<0.001, respectively).
IL-15 negatively correlated with eGDR (r=−0.436, p=0.021) in LADA and positively with HOMAIR in LADA and T1D (r=0.507, p<0.001; r=0.4209, p<0.001).
Conclusions.
Significantly higher IL-15 and IL-6 concentrations, HOMAIR, and markedly lower eGDR in newly diagnosed AD patients and first-degree relatives with positive anti-islet antibodies might suggest the role of these pro-inflammatory cytokines and insulin resistance in the pathogenesis of autoimmune diabetes.
IL-15 and IL-6 might be used as biomarkers of the risk of autoimmune diabetes development, in particular IL-15 for LADA.
Both methods of IR measurement appear equally useful for calculating insulin resistance in autoimmune diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Siewko, Katarzyna& Maciulewski, Rafal& Zielinska-Maciulewska, Anna& Popławska-Kita, Anna& Szumowski, Piotr& Wawrusewicz-Kurylonek, Natalia…[et al.]. 2019. Interleukin-6 and Interleukin-15 as Possible Biomarkers of the Risk of Autoimmune Diabetes Development. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125548
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Siewko, Katarzyna…[et al.]. Interleukin-6 and Interleukin-15 as Possible Biomarkers of the Risk of Autoimmune Diabetes Development. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1125548
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Siewko, Katarzyna& Maciulewski, Rafal& Zielinska-Maciulewska, Anna& Popławska-Kita, Anna& Szumowski, Piotr& Wawrusewicz-Kurylonek, Natalia…[et al.]. Interleukin-6 and Interleukin-15 as Possible Biomarkers of the Risk of Autoimmune Diabetes Development. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125548
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125548
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر