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Biochemical Changes in Blood of Patients with Duchenne Muscular Dystrophy Treated with Granulocyte-Colony Stimulating Factor
المؤلفون المشاركون
Kułak, Piotr
Sienkiewicz, Dorota
Okurowska-Zawada, Bożena
Paszko-Patej, Grażyna
Kułak, Wojciech
Sienkiewicz, Jerzy
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
In addition to the “gold standard” of therapy—steroids and gene therapy–there are experimental trials using granulocyte-colony stimulating factor (G-CSF) for patients with Duchenne muscular dystrophy (DMD).
The aim of this study was to present the biochemical changes in blood after repeating cycles of granulocyte-colony stimulating factor G-CSF therapy in children with DMD.
Materials and Methods.
Nineteen patients, aged 5 to 15 years, with diagnosed DMD confirmed by genetic tests, participated; nine were in wheelchairs, and ten were mobile and independent.
Patients had a clinical assessment and laboratory tests to evaluate hematological parameters and biochemistry.
G-CSF (5μg/kg/day) was given subcutaneously for five days during five nonconsecutive months over the course of a year.
Results.
We found a significant elevation of white blood cells, and the level of leucocytes returned to norm after each cycle.
No signs of any inflammatory process were found by monitoring C-reactive protein.
We did not detect significant changes in red blood cells, hemoglobin, and platelet levels or coagulation parameters.
We found a significant elevation of uric acid, with normalization after finishing each treatment cycle.
A significant decrease of the mean value activity of aspartate transaminase (AST) and alanine transaminase (ALT) of the G-CSF treatment was noted.
After each five days of therapy, the level of cholesterol was significantly lowered.
Also, glucose concentration significantly decreased after the fourth cycle.
Conclusions.
G-SCF decreased the aminotransferases activity, cholesterol level, and glucose level in patients with DMD, which may be important for patients with DMD and metabolic syndrome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sienkiewicz, Dorota& Kułak, Wojciech& Paszko-Patej, Grażyna& Okurowska-Zawada, Bożena& Sienkiewicz, Jerzy& Kułak, Piotr. 2019. Biochemical Changes in Blood of Patients with Duchenne Muscular Dystrophy Treated with Granulocyte-Colony Stimulating Factor. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125588
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sienkiewicz, Dorota…[et al.]. Biochemical Changes in Blood of Patients with Duchenne Muscular Dystrophy Treated with Granulocyte-Colony Stimulating Factor. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1125588
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sienkiewicz, Dorota& Kułak, Wojciech& Paszko-Patej, Grażyna& Okurowska-Zawada, Bożena& Sienkiewicz, Jerzy& Kułak, Piotr. Biochemical Changes in Blood of Patients with Duchenne Muscular Dystrophy Treated with Granulocyte-Colony Stimulating Factor. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125588
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125588
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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