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Linezolid Inhibited Synthesis of ATP in Mitochondria: Based on GC-MS Metabolomics and HPLC Method
المؤلفون المشاركون
Wen, Congcong
Hu, Lufeng
Ye, Xuemei
Huang, Aifang
Lin, Guanyang
Wang, Xianqin
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Linezolid has been widely used in serious infections for its effective inhibiting effect against multidrug-resistant gram-positive pathogens.
However, linezolid caused severe adverse reactions, such as thrombocytopenia, anaemia, optic neuropathy, and near-fatal serotonin syndrome.
In order to investigate the toxicity of linezolid, twenty-four Sprague-Dawley rats were randomly divided into: control group (n=7), low-group (n=8), and high-group (n=9).
The rats of low-group and high-group were given by gavage with linezolid 60 and 120 mg/kg/day for 7 days, respectively.
The serum concentration of linezolid was determined by high performance liquid chromatography (HPLC); blood metabolic change was analyzed by gas chromatography-mass spectrometer (GC-MS).
Adenosine triphosphate (ATP) concentration in HepG2-C3A after being cultured with linezolid was determined by HPLC.
The results showed that there were six metabolites and nine metabolites had statistical differences in low-group and high-group (P<0.05).
The trimethyl phosphate was the most significant indicator in those changed metabolites.
Except for d-glucose which was slightly increased in low-group, octadecanoic acid, cholest-5-ene, hexadecanoic acid, α-linolenic acid, eicosapentaenoic acid, 9,12-Octadecadienoic acid, and docosahexaenoic acid were all decreased in low-group and high-group.
ATP concentration was decreased in HepG2-C3A after cultured with linezolid.
In conclusion, the toxicity of linezolid is related to its serum concentration.
Linezolid may inhibit the synthesis of ATP and fatty acid.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ye, Xuemei& Huang, Aifang& Wang, Xianqin& Wen, Congcong& Hu, Lufeng& Lin, Guanyang. 2018. Linezolid Inhibited Synthesis of ATP in Mitochondria: Based on GC-MS Metabolomics and HPLC Method. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125651
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ye, Xuemei…[et al.]. Linezolid Inhibited Synthesis of ATP in Mitochondria: Based on GC-MS Metabolomics and HPLC Method. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1125651
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ye, Xuemei& Huang, Aifang& Wang, Xianqin& Wen, Congcong& Hu, Lufeng& Lin, Guanyang. Linezolid Inhibited Synthesis of ATP in Mitochondria: Based on GC-MS Metabolomics and HPLC Method. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125651
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125651
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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