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Icaritin: A Novel Natural Candidate for Hematological Malignancies Therapy
المؤلفون المشاركون
Yang, Xiao-Jing
Li, Zi-Jian
Xi, Ya-Ming
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Hematological malignancies including leukemia and lymphoma can severely impact human health.
With the current therapies combined with chemotherapy, stem cell transplantation, radiotherapy, and immunotherapy, the prognosis of hematologic malignancies improved significantly.
However, most hematological malignancies are still incurable.
Therefore, research for novel treatment options was continuing with the natural product as one source.
Icaritin is a compound extracted from a traditional Chinese herb, Epimedium Genus, and demonstrated an antitumor effect in various neoplasms including hematological malignancies such as leukemia, lymphoma, and multiple myeloma.
In hematological malignancies, icaritin showed multiple cytotoxic effects to induce apoptosis, arrest the cell cycle, inhibit proliferation, promote differentiation, restrict metastasis and infiltration, and suppress the oncogenic virus.
The proved underlying mechanisms of the cytotoxic effects of icaritin are different in various cell types of hematological malignancies but associated with the critical cell signal pathway, including PI3K/Akt, JAK/STAT3, and MAPK/ERK/JNK.
Although the primary target of icaritin is still unspecified, the existing evidence indicates that icaritin is a potential novel therapeutic agent for neoplasms as with hematological malignancies.
Here, in the field of hematology, we reviewed the reported activity of icaritin in hematologic malignancies and the underlying mechanisms and recognized icaritin as a candidate for therapy of hematological malignancies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Xiao-Jing& Xi, Ya-Ming& Li, Zi-Jian. 2019. Icaritin: A Novel Natural Candidate for Hematological Malignancies Therapy. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125658
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Xiao-Jing…[et al.]. Icaritin: A Novel Natural Candidate for Hematological Malignancies Therapy. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1125658
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Xiao-Jing& Xi, Ya-Ming& Li, Zi-Jian. Icaritin: A Novel Natural Candidate for Hematological Malignancies Therapy. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125658
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125658
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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