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Analysis of Protein–Protein Functional Associations by Using Gene Ontology and KEGG Pathway
المؤلفون المشاركون
Huang, Tao
Zhang, Yu-Hang
Pan, Xiaoyong
Chen, Lei
Cai, Yu-Dong
Yuan, Fei
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Protein–protein interaction (PPI) plays an extremely remarkable role in the growth, reproduction, and metabolism of all lives.
A thorough investigation of PPI can uncover the mechanism of how proteins express their functions.
In this study, we used gene ontology (GO) terms and biological pathways to study an extended version of PPI (protein–protein functional associations) and subsequently identify some essential GO terms and pathways that can indicate the difference between two proteins with and without functional associations.
The protein–protein functional associations validated by experiments were retrieved from STRING, a well-known database on collected associations between proteins from multiple sources, and they were termed as positive samples.
The negative samples were constructed by randomly pairing two proteins.
Each sample was represented by several features based on GO and KEGG pathway information of two proteins.
Then, the mutual information was adopted to evaluate the importance of all features and some important ones could be accessed, from which a number of essential GO terms or KEGG pathways were identified.
The final analysis of some important GO terms and one KEGG pathway can partly uncover the difference between proteins with and without functional associations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yuan, Fei& Pan, Xiaoyong& Chen, Lei& Zhang, Yu-Hang& Huang, Tao& Cai, Yu-Dong. 2019. Analysis of Protein–Protein Functional Associations by Using Gene Ontology and KEGG Pathway. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125729
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yuan, Fei…[et al.]. Analysis of Protein–Protein Functional Associations by Using Gene Ontology and KEGG Pathway. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1125729
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yuan, Fei& Pan, Xiaoyong& Chen, Lei& Zhang, Yu-Hang& Huang, Tao& Cai, Yu-Dong. Analysis of Protein–Protein Functional Associations by Using Gene Ontology and KEGG Pathway. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125729
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125729
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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