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Analysis of Protein–Protein Functional Associations by Using Gene Ontology and KEGG Pathway
Joint Authors
Huang, Tao
Zhang, Yu-Hang
Pan, Xiaoyong
Chen, Lei
Cai, Yu-Dong
Yuan, Fei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Protein–protein interaction (PPI) plays an extremely remarkable role in the growth, reproduction, and metabolism of all lives.
A thorough investigation of PPI can uncover the mechanism of how proteins express their functions.
In this study, we used gene ontology (GO) terms and biological pathways to study an extended version of PPI (protein–protein functional associations) and subsequently identify some essential GO terms and pathways that can indicate the difference between two proteins with and without functional associations.
The protein–protein functional associations validated by experiments were retrieved from STRING, a well-known database on collected associations between proteins from multiple sources, and they were termed as positive samples.
The negative samples were constructed by randomly pairing two proteins.
Each sample was represented by several features based on GO and KEGG pathway information of two proteins.
Then, the mutual information was adopted to evaluate the importance of all features and some important ones could be accessed, from which a number of essential GO terms or KEGG pathways were identified.
The final analysis of some important GO terms and one KEGG pathway can partly uncover the difference between proteins with and without functional associations.
American Psychological Association (APA)
Yuan, Fei& Pan, Xiaoyong& Chen, Lei& Zhang, Yu-Hang& Huang, Tao& Cai, Yu-Dong. 2019. Analysis of Protein–Protein Functional Associations by Using Gene Ontology and KEGG Pathway. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125729
Modern Language Association (MLA)
Yuan, Fei…[et al.]. Analysis of Protein–Protein Functional Associations by Using Gene Ontology and KEGG Pathway. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1125729
American Medical Association (AMA)
Yuan, Fei& Pan, Xiaoyong& Chen, Lei& Zhang, Yu-Hang& Huang, Tao& Cai, Yu-Dong. Analysis of Protein–Protein Functional Associations by Using Gene Ontology and KEGG Pathway. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125729