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NAT2 Gene Polymorphisms in Turkish Patients with Psoriasis Vulgaris
المؤلفون المشاركون
Dursun, Recep
Dursun, Hatice Gül
Zamani, Ayşe Gül
Yıldırım, Mahmut Selman
Çınar, İlknur
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-11
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Psoriasis is a common, chronic, and autoimmune skin disease.
Factors that play a role in etiopathogenesis of psoriasis include internal factors such as genetic susceptibility and immunological factors and external factors such as stress, infection, trauma, drug, and environmental compounds.
N-acetyltransferase 2 (NAT2) is a xenobiotic enzyme that is involved in the metabolism of drugs, environmental toxins, and carcinogens.
In this study, we aimed to demonstrate whether the variations in the NAT2 gene lead to a predisposition to psoriasis by affecting the enzyme's ability to metabolize drugs and environmental components or not.
Three polymorphisms (rs1799929, rs1799930, and rs1799931) in NAT2 gene were genotyped and compared by real-time PCR method in 260 psoriasis vulgaris patients and 200 healthy controls.
There was no difference in the genotype distributions and allele frequencies of polymorphisms between psoriasis vulgaris patients and controls.
When the effects of polymorphisms on the clinical features of the disease, such as onset age and severity, are assessed, it has been found that rs1799930 and rs1799929 are, respectively, associated with early onset age and severity of the disease.
In conclusion, rs1799929, rs1799930, and rs1799931 polymorphisms of the NAT-2 gene do not appear to be a risk factor for the development of psoriasis.
Conversely, they may have an effect on either more severe or early onset cases of the disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dursun, Recep& Dursun, Hatice Gül& Zamani, Ayşe Gül& Yıldırım, Mahmut Selman& Çınar, İlknur. 2018. NAT2 Gene Polymorphisms in Turkish Patients with Psoriasis Vulgaris. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1125745
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dursun, Recep…[et al.]. NAT2 Gene Polymorphisms in Turkish Patients with Psoriasis Vulgaris. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1125745
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dursun, Recep& Dursun, Hatice Gül& Zamani, Ayşe Gül& Yıldırım, Mahmut Selman& Çınar, İlknur. NAT2 Gene Polymorphisms in Turkish Patients with Psoriasis Vulgaris. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1125745
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125745
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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