Plasma miR-22-5p, miR-132-5p, and miR-150-3p Are Associated with Acute Myocardial Infarction
المؤلفون المشاركون
Li, Huixian
Zhang, Pengxiang
Li, Fangjiang
Yuan, Guili
Wang, Xiaoyuan
Zhang, Aiai
Li, Feixing
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-24
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Circulating microRNAs (miRNAs) are potential biomarkers for cardiovascular diseases.
Our study aimed to determine whether miR-22-5p, miR-132-5p, and miR-150-3p represent novel biomarkers for acute myocardial infarction (AMI).
Plasma samples were isolated from 35 AMI patients and 55 matched controls.
Total RNA was extracted, and quantitative real-time PCR and ELISA were performed to investigate the expressions of miRNAs and cardiac troponin I (cTnI), respectively.
We found that plasma levels of miR-22-5p and miR-150-3p were significantly higher during the early stage of AMI and their expression levels peaked earlier than cTnI.
Conversely, circulating miR-132-5p was sustained at a low level during the early phase of AMI.
All three circulating miRNAs were correlated with plasma cTnI levels.
A receiver operating characteristic (ROC) analysis suggested that each single miRNA had considerable diagnostic efficacy for AMI.
Moreover, combining the three miRNAs improved their diagnostic efficacy.
Furthermore, neither heparin nor medications for coronary heart disease (CHD) affected plasma levels of miR-22-5p and miR-132-5p, but circulating miR-150-3p was downregulated by medications for CHD.
We concluded that plasma miR-22-5p, miR-132-5p, and miR-150-3p may serve as candidate diagnostic biomarkers for early diagnosis of AMI.
Moreover, a panel consisting of these three miRNAs may achieve a higher diagnostic value.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Huixian& Zhang, Pengxiang& Li, Fangjiang& Yuan, Guili& Wang, Xiaoyuan& Zhang, Aiai…[et al.]. 2019. Plasma miR-22-5p, miR-132-5p, and miR-150-3p Are Associated with Acute Myocardial Infarction. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1125746
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Huixian…[et al.]. Plasma miR-22-5p, miR-132-5p, and miR-150-3p Are Associated with Acute Myocardial Infarction. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1125746
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Huixian& Zhang, Pengxiang& Li, Fangjiang& Yuan, Guili& Wang, Xiaoyuan& Zhang, Aiai…[et al.]. Plasma miR-22-5p, miR-132-5p, and miR-150-3p Are Associated with Acute Myocardial Infarction. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1125746
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125746
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر