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Tumor Microenvironment and Cell Fusion
المؤلفون المشاركون
Jiang, Erhui
Yan, Tinglin
Xu, Zhi
Shang, Zhengjun
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Cell fusion is a highly regulated biological process that occurs under both physiological and pathological conditions.
The cellular and extracellular environment is critical for the induction of the cell–cell fusion.
Aberrant cell fusion is initiated during tumor progression.
Tumor microenvironment is a complex dynamic system formed by the interaction between tumor cells and their surrounding cells.
Cell–cell fusion mediates direct interaction between tumor cells and their surrounding cells and is associated with tumor initiation and progression.
Various microenvironmental factors affect cell fusion in tumor microenvironment and generate hybrids that acquire genomes of both parental cells and exhibit novel characteristics, such as tumor stem cell-like properties, radioresistance, drug resistance, immune evasion, and enhanced migration and invasion abilities, which are closely related to the initiation, invasion, and metastasis of tumor.
The phenotypic characteristics of hybrids are based on the phenotypes of parental cells, and the fusion of tumor cells with diverse types of microenvironmental fusogenic cells is concomitant with phenotypic heterogeneity.
This review highlights the types of fusogenic cells in tumor microenvironment that can fuse with tumor cells and their specific significance and summarizes the various microenvironmental factors affecting tumor cell fusion.
This review may be used as a reference to develop strategies for future research on tumor cell fusion and the exploration of cell fusion-based antitumor therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Erhui& Yan, Tinglin& Xu, Zhi& Shang, Zhengjun. 2019. Tumor Microenvironment and Cell Fusion. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1125749
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Erhui…[et al.]. Tumor Microenvironment and Cell Fusion. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1125749
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Erhui& Yan, Tinglin& Xu, Zhi& Shang, Zhengjun. Tumor Microenvironment and Cell Fusion. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1125749
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125749
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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