Eupatilin Inhibits Renal Cancer Growth by Downregulating MicroRNA-21 through the Activation of YAP1
المؤلفون المشاركون
Zhong, Weifeng
Wu, Zhiming
Chen, Nanhui
Zhong, Kaihua
Lin, Yifeng
Jiang, Huiming
Wan, Pei
Lu, Shanming
Yang, Lawei
Liu, Siping
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Renal cell carcinoma (RCC) is the second most common human urinary tumor.
Eupatilin is the main active ingredient of the traditional Chinese medicine Artemisia asiatica.
The effect of Eupatilin on RCC and the underlying mechanism remain unknown.
Here, we investigated the anticancer effects and mechanisms of Eupatilin in RCC in vivo and in vitro, laying an experimental foundation for the clinical application of Eupatilin in the treatment of RCC.
The results showed that Eupatilin significantly inhibited 786-O cell viability and migration and promoted apoptosis.
Eupatilin inhibited the expression of miR-21 in 786-O cells, and overexpression of miR-21 suppressed the effect of Eupatilin on viability, apoptosis, and migration in 786-O cells.
Eupatilin inhibited the growth of renal tumors in nude mice by downregulating miR-21.
YAP1, which was identified as a target of miR-21, showed significantly lower expression in RCC tissues than in healthy tissues.
miR-21 significantly inhibited YAP1 protein expression in 786-O cells and tumor tissues isolated from nude mice, and YAP1 attenuated the effect of miR-21 on the viability, apoptosis, and migration of 786-O cells.
In conclusion, Eupatilin inhibited the expression of miR-21, which mediated the proapoptotic and antimigratory effects of Eupatilin by suppressing YAP1 in renal cancer cells.
These results suggested that Eupatilin could be a potent agent for the treatment of RCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhong, Weifeng& Wu, Zhiming& Chen, Nanhui& Zhong, Kaihua& Lin, Yifeng& Jiang, Huiming…[et al.]. 2019. Eupatilin Inhibits Renal Cancer Growth by Downregulating MicroRNA-21 through the Activation of YAP1. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1125751
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhong, Weifeng…[et al.]. Eupatilin Inhibits Renal Cancer Growth by Downregulating MicroRNA-21 through the Activation of YAP1. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1125751
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhong, Weifeng& Wu, Zhiming& Chen, Nanhui& Zhong, Kaihua& Lin, Yifeng& Jiang, Huiming…[et al.]. Eupatilin Inhibits Renal Cancer Growth by Downregulating MicroRNA-21 through the Activation of YAP1. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1125751
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125751
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر