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Skeletal Site-Specific Response of Jawbones and Long Bones to Surgical Interventions in Rats Treated with Zoledronic Acid
المؤلفون المشاركون
Zheng, Li Wu
Lu, Weijia William
Rao, Nian Jing
Wang, Jing Yi
Huo, Lei
Yu, Ru Qing
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Bisphosphonates (BPs) have been extensively used for management of bone diseases with pathologically high resorption.
Despite the great clinical benefits, a severe complication known as medication-related osteonecrosis of the jaw (MRONJ) has been reported.
It is found that most of the reported MRONJ cases were limited in the jawbones/craniofacial bones instead of long bones.
The present study aims to investigate the differential bone response to surgical procedures between jawbones and long bones exposed to BPs.
Forty-eight skeletal mature Sprague Dawley female rats were administered oncologic dose of zoledronic acid (ZA) or normal saline for 4 weeks and then subjected to tooth extraction on the mandible and maxilla, and a bone defect creation on the femur.
After surgical procedures, ZA or saline treatment were continued until sacrifice at week 2, week 4, and week 8, post-operatively.
The samples were subjected to micro-computerized tomography (micro-CT) and histological assessment.
Osteonecrosis was only found in jawbones in ZA-treated rats.
ZA-treated rats showed significantly higher bone mineral density with greater bone volume in all surgical sites than that in the controls.
The length of exposure of ZA did not seem to affect trabecular microstructure, and it only showed higher bone volume and BMD with longer healing time which is expected in the healing process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Jing Yi& Huo, Lei& Yu, Ru Qing& Rao, Nian Jing& Lu, Weijia William& Zheng, Li Wu. 2019. Skeletal Site-Specific Response of Jawbones and Long Bones to Surgical Interventions in Rats Treated with Zoledronic Acid. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1125846
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Jing Yi…[et al.]. Skeletal Site-Specific Response of Jawbones and Long Bones to Surgical Interventions in Rats Treated with Zoledronic Acid. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1125846
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Jing Yi& Huo, Lei& Yu, Ru Qing& Rao, Nian Jing& Lu, Weijia William& Zheng, Li Wu. Skeletal Site-Specific Response of Jawbones and Long Bones to Surgical Interventions in Rats Treated with Zoledronic Acid. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1125846
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125846
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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