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In Vivo Evaluation of Short-Term Performance of New Three-Layer Collagen-Based Vascular Graft Designed for Low-Flow Peripheral Vascular Reconstructions
المؤلفون المشاركون
Grus, Tomas
Lambert, Lukas
Mlcek, Mikulas
Chlup, Hynek
Spacek, Miroslav
Burgetova, Andrea
Lindner, Jaroslav
Eva, Honsová
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
The aim of this study was to evaluate short-term patency of the new prosthetic graft and its structural changes after explantation.
Methods.
The study team developed a three-layer conduit composed of a scaffold made from polyester coated with collagen from the inner and outer side with an internal diameter of 6 mm.
The conduit was implanted as a bilateral bypass to the carotid artery in 7 sheep and stenosis was created in selected animals.
After a period of 161 days, the explants were evaluated as gross and microscopic specimens.
Results.
The initial flow rate (median ± IQR) in grafts with and without artificial stenosis was 120±79 ml/min and 255±255 ml/min, respectively.
Graft occlusion occurred after 99 days in one of 13 conduits (patency rate: 92%).
Wall-adherent thrombi occurred only in sharp curvatures in two grafts.
Microscopic evaluation showed good engraftment and preserved structure in seven conduits; inflammatory changes with foci of bleeding, necrosis, and disintegration in four conduits; and narrowing of the graft due to thickening of the wall with multifocal separation of the outer layer in two conduits.
Conclusions.
This study demonstrates good short-term patency rates of a newly designed three-layer vascular graft even in low-flow conditions in a sheep model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Grus, Tomas& Lambert, Lukas& Mlcek, Mikulas& Chlup, Hynek& Eva, Honsová& Spacek, Miroslav…[et al.]. 2018. In Vivo Evaluation of Short-Term Performance of New Three-Layer Collagen-Based Vascular Graft Designed for Low-Flow Peripheral Vascular Reconstructions. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1125877
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Grus, Tomas…[et al.]. In Vivo Evaluation of Short-Term Performance of New Three-Layer Collagen-Based Vascular Graft Designed for Low-Flow Peripheral Vascular Reconstructions. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1125877
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Grus, Tomas& Lambert, Lukas& Mlcek, Mikulas& Chlup, Hynek& Eva, Honsová& Spacek, Miroslav…[et al.]. In Vivo Evaluation of Short-Term Performance of New Three-Layer Collagen-Based Vascular Graft Designed for Low-Flow Peripheral Vascular Reconstructions. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1125877
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125877
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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