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Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells
المؤلفون المشاركون
Takegawa, Daisuke
Yumoto, Hiromichi
Matsuo, Takashi
Hirao, Kouji
Nakanishi, Tadashi
Kuramoto, Hitomi
Hosokawa, Yuki
Washio, Ayako
Kitamura, Chiaki
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-21
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Caffeic acid phenethyl ester (CAPE), the main component of propolis, has various biological activities including anti-inflammatory effect and wound healing promotion.
Odontoblasts located in the outermost layer of dental pulp play crucial roles such as production of growth factors and formation of hard tissue termed reparative dentin in host defense against dental caries.
In this study, we investigated the effects of CAPE on the upregulation of vascular endothelial growth factor (VEGF) and calcification activities of odontoblasts, leading to development of novel therapy for dental pulp inflammation caused by dental caries.
CAPE significantly induced mRNA expression and production of VEGF in rat clonal odontoblast-like KN-3 cells cultured in normal medium or osteogenic induction medium.
CAPE treatment enhanced nuclear factor-kappa B (NF-κB) transcription factor activation, and furthermore, the specific inhibitor of NF-κB significantly reduced VEGF production.
The expression of VEGF receptor- (VEGFR-) 2, not VEGFR-1, was up regulated in KN-3 cells treated with CAPE.
In addition, VEGF significantly increased mineralization activity in KN-3 cells.
These findings suggest that CAPE might be useful as a novel biological material for the dental pulp conservative therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kuramoto, Hitomi& Hirao, Kouji& Yumoto, Hiromichi& Hosokawa, Yuki& Nakanishi, Tadashi& Takegawa, Daisuke…[et al.]. 2019. Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1126003
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kuramoto, Hitomi…[et al.]. Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1126003
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kuramoto, Hitomi& Hirao, Kouji& Yumoto, Hiromichi& Hosokawa, Yuki& Nakanishi, Tadashi& Takegawa, Daisuke…[et al.]. Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1126003
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126003
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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