Alleviation of Cartilage Destruction by Sinapic Acid in Experimental Osteoarthritis
المؤلفون المشاركون
Cai, Dawei
Huff, Thomas W.
Liu, Jun
Yuan, Tangbo
Wei, Zijian
Qin, Jian
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Sinapic acid (SA) modulates the nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling pathway in chondrocytes.
In order to test the hypothesis that SA is protective against the development of osteoarthritis (OA), primary mouse chondrocytes were treated in vitro with SA and the promoter transactivation activity of heme oxygenase 1 (HO-1), nuclear translocation of Nrf2, and protein expression of HO-1 were assayed.
To test the hypothesis in vivo, a destabilization of the medial meniscus (DMM) model was used to induce OA in the knees of mice and SA was delivered orally to the experimental group.
The chondrocytes were harvested for further analysis.
The expression of HO-1 was similarly upregulated in cartilage from both the experimental mice and human chondrocytes from osteoarthritic knees.
SA was found to enhance the promoter transactivation activity of heme oxygenase 1 (HO-1) and increase the expression of Nrf2 and HO-1 in primary chondrocytes.
Histopathologic scores showed that the damage induced by the DMM model was significantly lower in the SA treatment group.
The addition of a HO-1 inhibitor with SA did not show additional benefit over SA alone in terms of cartilage degradation or histopathologic scores.
The expression of TNF-α, IL-1β, IL-6, MMP-1, MMP-3, MMP-13, ADAMTS4, and ADAMTS5 was significantly reduced both in vitro and in vivo by the presence of SA.
Protein expressions of HO-1 and Nrf2 were substantially increased in knee cartilage of mice that received oral SA.
Our results suggest that SA should be further explored as a preventative treatment for OA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cai, Dawei& Huff, Thomas W.& Liu, Jun& Yuan, Tangbo& Wei, Zijian& Qin, Jian. 2019. Alleviation of Cartilage Destruction by Sinapic Acid in Experimental Osteoarthritis. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126158
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cai, Dawei…[et al.]. Alleviation of Cartilage Destruction by Sinapic Acid in Experimental Osteoarthritis. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1126158
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cai, Dawei& Huff, Thomas W.& Liu, Jun& Yuan, Tangbo& Wei, Zijian& Qin, Jian. Alleviation of Cartilage Destruction by Sinapic Acid in Experimental Osteoarthritis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126158
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126158
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر