Baicalein Accelerates Tendon-Bone Healing via Activation of Wntβ-Catenin Signaling Pathway in Rats
المؤلفون المشاركون
Li, Tao
Tian, Xinggui
Jiang, Huaji
Chen, Yuhui
Ao, Xiang
Chen, Chuan
Zhang, Wentao
He, Feilin
Liao, Xiaoqing
Jiang, Xiaocheng
Zhang, Zhongmin
Zhang, Xintao
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Tendon-bone healing is a reconstructive procedure which requires a tendon graft healing to a bone tunnel or to the surface of bone after the junction injury between tendon, ligament, and bone.
The surgical reattachment of tendon to bone often fails due to regeneration failure of the specialized tendon-bone junction.
Materials and Methods.
An extra-articular tendon-bone healing rat model was established to discuss the effect of the baicalein 10 mg/(kg·d) in accelerating tendon-bone healing progress.
Also, tendon-derived stem cells (TDSCs) were treated with various concentrations of baicalein or dickkopf-1 (DKK-1) to stimulate differentiation for 14 days.
Results.
In vivo, tendon-bone healing strength of experiment group was obviously stronger than the control group in 3 weeks as well as in 6 weeks.
And there were more mature fibroblasts, more Sharpey fibers, and larger new bone formation area treated intragastrically with baicalein compared with rats that were treated with vehicle for 3 weeks and 6 weeks.
In vitro, after induction for 14 days, the expressions of osteoblast differentiation markers, that is, alkaline phosphatase (ALP), runt-related transcription factor 2 (Runx2), osteocalcin (OCN), osterix (OSX), and collagen I, were upregulated and Wnt/β-catenin signaling pathway was enhanced in TDSCs.
The effect of DKK-1 significantly reduced the effect of baicalein on the osteogenic differentiation.
Conclusion.
These data suggest that baicalein may stimulate TDSCs osteogenic differentiation via activation of Wnt/β-catenin signaling pathway to accelerate tendon-bone healing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Xinggui& Jiang, Huaji& Chen, Yuhui& Ao, Xiang& Chen, Chuan& Zhang, Wentao…[et al.]. 2018. Baicalein Accelerates Tendon-Bone Healing via Activation of Wntβ-Catenin Signaling Pathway in Rats. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126161
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Xinggui…[et al.]. Baicalein Accelerates Tendon-Bone Healing via Activation of Wntβ-Catenin Signaling Pathway in Rats. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126161
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Xinggui& Jiang, Huaji& Chen, Yuhui& Ao, Xiang& Chen, Chuan& Zhang, Wentao…[et al.]. Baicalein Accelerates Tendon-Bone Healing via Activation of Wntβ-Catenin Signaling Pathway in Rats. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126161
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126161
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر