Effects of Inonotus obliquus Polysaccharides on Proliferation, Invasion, Migration, and Apoptosis of Osteosarcoma Cells
المؤلفون المشاركون
Su, Baohui
Yan, Xuezhi
Li, Yuezhong
Zhang, Junshan
Xia, Xiaoyan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
To observe the effect of Inonotus obliquus polysaccharide (IOP) on the proliferation, invasion, migration, and apoptosis of osteosarcoma cells and to elucidate its underlying molecular mechanism.
Methods.
IOP was extracted from Inonotus obliquus, human osteosarcoma MG-63 cells and U2OS cells were cultured in vitro, and the effects of IOP on the proliferation, migration, invasion, and apoptosis of MG-63 cells and U2OS cells were determined by CCK-8 assays, cell scratch assays, transwell assays, and flow cytometry, respectively.
Western blot was used to detect the expression of related proteins in the Akt/mTOR and NF-κB signaling pathways.
Results.
Compared with the control group, MG-63 cells and U2OS cells treated with IOP of 80 μg/ml, 160 μg/ml, and 320 μ g/ml in the experimental group had significantly lower proliferation activity, decreased migration and invasion ability, and increased apoptosis rate (P<0.05).
Furthermore, IOP could significantly inhibit the activation of the Akt/mTOR and NF-κB signaling pathway (P<0.05).
Conclusion.
IOP can regulate the proliferation, migration, invasion, and apoptosis of osteosarcoma cells by inhibiting the activation of the Akt/mTOR signaling pathway.
It has antitumor activity on osteosarcoma and has the potential of clinical application in osteosarcoma treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Su, Baohui& Yan, Xuezhi& Li, Yuezhong& Zhang, Junshan& Xia, Xiaoyan. 2020. Effects of Inonotus obliquus Polysaccharides on Proliferation, Invasion, Migration, and Apoptosis of Osteosarcoma Cells. Analytical Cellular Pathology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1126172
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Su, Baohui…[et al.]. Effects of Inonotus obliquus Polysaccharides on Proliferation, Invasion, Migration, and Apoptosis of Osteosarcoma Cells. Analytical Cellular Pathology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1126172
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Su, Baohui& Yan, Xuezhi& Li, Yuezhong& Zhang, Junshan& Xia, Xiaoyan. Effects of Inonotus obliquus Polysaccharides on Proliferation, Invasion, Migration, and Apoptosis of Osteosarcoma Cells. Analytical Cellular Pathology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1126172
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126172
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر