The Diagnostic and Clinical Significance of TFE3 Immunohistochemical Nuclear Expression in Solitary Fibrous Tumour
المؤلفون المشاركون
Zhou, Jun
Zhou, Luting
Xu, Haiming
Wang, Anran
Wang, Chaofu
Yu, Guoli
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The expression of TFE3 (transcription factor E3) in solitary fibrous tumours (SFTs) and their histologic mimickers was investigated, and the diagnostic value and clinical significance of TFE3 nuclear expression in SFTs were explored.
Immunohistochemical analysis for TFE3 was performed on 50 cases of SFTs that were surgically resected.
The controls were sample tissues from malignant peripheral nerve sheath tumour, synovial sarcoma, dedifferentiated liposarcoma, spindle cell lipoma, and dermatofibrosarcoma protuberans.
The survival of patients with TFE3-positive and TFE3-negative expressions was assessed through the Kaplan-Meier analysis.
In 44 of 50 (88%) SFTs, nuclear immunoreactivity for TFE3 was detected.
The TFE3 expression was negative in all samples of synovial sarcoma, malignant peripheral nerve sheath tumour, dermatofibrosarcoma protuberans, and spindle cell lipoma and weakly positive in 2 of 10 cases of dedifferentiated liposarcoma.
Fluorescence in situ hybridization (FISH) confirmed that the expression of the TFE3 protein is not caused by gene translocation.
There was no statistical significance between the association of the TFE3 expression and SFT patient prognosis.
Therefore, TFE3 is capable of enhancing the differential diagnosis of SFTs and their histologic mimickers and can be potentially used as a diagnostic marker.
The findings also offer valuable insights into SFT diagnosis, aetiology, and associated molecular mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Luting& Wang, Anran& Yu, Guoli& Zhou, Jun& Xu, Haiming& Wang, Chaofu. 2020. The Diagnostic and Clinical Significance of TFE3 Immunohistochemical Nuclear Expression in Solitary Fibrous Tumour. Analytical Cellular Pathology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1126200
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Luting…[et al.]. The Diagnostic and Clinical Significance of TFE3 Immunohistochemical Nuclear Expression in Solitary Fibrous Tumour. Analytical Cellular Pathology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1126200
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Luting& Wang, Anran& Yu, Guoli& Zhou, Jun& Xu, Haiming& Wang, Chaofu. The Diagnostic and Clinical Significance of TFE3 Immunohistochemical Nuclear Expression in Solitary Fibrous Tumour. Analytical Cellular Pathology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1126200
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126200
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر