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The Role of IL-6RA in UHMWPE Promotes Proliferation in Fibro-Like Synovial Cells
المؤلفون المشاركون
Pang, Xianlun
Yang, Jiang
Zhen, Xiaoli
Nie, Hai
Qin, Hao
Huang, Lingyuan
Zhang, Lijie
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
UHMWPE granule could induce macrophages and inflammatory responses in interfacial tissues, which eliminated the wear debris of UHMWPE component and further induced dissolution of the surrounding bone, leading aseptic loosening.
However, the mechanism of synovial cells, especially fibroblast-like synovial (FLS) cells response to UHMWPE, remains unknown.
Herein we choose FLS cells as research object.
Vimentin (+) CD68 (-) was identified by flow cytometry and immunofluorescent staining assay, and the cells were identified as FLS cells, which was consistent with the experimental requirements.
The inhibitory evaluation showed that UHMWPE could significantly promote the proliferation and inhibit apoptosis of FLS cells in dose- and time-dependent manners and increase the levels of proinflammatory cytokines, including IL-6, IL-1β, TNF-α, PGE2, MMP2, and LOX.
UHMWPE also can induce the expression of mIL-6R protein in FLS cells and further investigate the relationship between apoptosis and inflammation.
Interestingly enough, when we added the interleukin-6 receptor antagonist (IL-6RA), the expression levels of proapoptosis-related proteins increased; in other words, UHMWPE-induced antiapoptosis diminished by IL-6RA (50 μg/ml).
Taken together, these findings clearly demonstrated that UHMWPE promote growth in FLS cells through upregulating inflammatory factors to produce antiapoptotic effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pang, Xianlun& Yang, Jiang& Zhen, Xiaoli& Nie, Hai& Qin, Hao& Huang, Lingyuan…[et al.]. 2018. The Role of IL-6RA in UHMWPE Promotes Proliferation in Fibro-Like Synovial Cells. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126230
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pang, Xianlun…[et al.]. The Role of IL-6RA in UHMWPE Promotes Proliferation in Fibro-Like Synovial Cells. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126230
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pang, Xianlun& Yang, Jiang& Zhen, Xiaoli& Nie, Hai& Qin, Hao& Huang, Lingyuan…[et al.]. The Role of IL-6RA in UHMWPE Promotes Proliferation in Fibro-Like Synovial Cells. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126230
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126230
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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