The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells

المؤلفون المشاركون

El-Sibai, Mirvat
El Atat, Oula
Jaafar, Leila
Al-Koussa, Houssam
Tashjian, Hagop

المصدر

Analytical Cellular Pathology

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-01-31

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Astrocytomas are primary malignant brain tumors that originate from astrocytes.

Grade IV astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain parenchyma.

The Rho family of small GTPases, which includes Rac1, Cdc42, and RhoA, is an important family whose members are key regulators of the invasion and migration of glioblastoma cells.

In this review, we describe the role played by the Rho family of GTPases in the regulation of the invasion and migration of glioblastoma cells.

Specifically, we focus on the role played by RhoA, Rac1, RhoG, and Cdc42 in cell migration through rearrangement of actin cytoskeleton, cell adhesion, and invasion.

Finally, we highlight the importance of potentially targeting Rho GTPases in the treatment of glioblastoma.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Al-Koussa, Houssam& El Atat, Oula& Jaafar, Leila& Tashjian, Hagop& El-Sibai, Mirvat. 2020. The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells. Analytical Cellular Pathology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1126233

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Al-Koussa, Houssam…[et al.]. The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells. Analytical Cellular Pathology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1126233

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Al-Koussa, Houssam& El Atat, Oula& Jaafar, Leila& Tashjian, Hagop& El-Sibai, Mirvat. The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells. Analytical Cellular Pathology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1126233

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1126233