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Comparative Analysis of Immunoactivation by Nanosecond Pulsed Electric Fields and PD-1 Blockade in Murine Hepatocellular Carcinoma
المؤلفون المشاركون
Chen, Xinhua
Yimingjiang, Maiweilidan
Tuergan, Talaiti
Shao, Yingmei
Zhang, RuiQing
Aihaiti, Kasimu
Xue, Jing
Aji, Tuerganaili
Zhang, Wei
Wen, Hao
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Nanosecond pulsed electric field (NsPEF) ablation effectively eliminates early-stage hepatocellular carcinoma (HCC) by local ablation and advanced HCC by inducing a remarkable and sustained host immune response.
However, this approach is not sufficient to prevent cancer progression, and complementary approaches are necessary for effective immunotherapy.
In this study, we evaluated the immunoactivating effects and mechanisms of action of nsPEF ablation and PD-1 blockade on an HCC orthotopic xenograft mouse model.
Briefly, 24 C57BL-6J tumor-bearing mice were randomly assigned to three groups: nsPEF ablation group, anti-PD-1 administration group, and untreated control group.
Tumor-infiltrating T, B, and NK cell levels and plasma concentrations of Th1 (IL-2, IFN-γ, and TNF-α), Th2 (IL-4, IL-5, IL-6, and IL-10), Th9 (IL-9), and Th17 (IL-17A, IL-17F, IL-21, and IL-22) cytokines were evaluated.
Both nsPEF ablation and anti-PD-1 treatment induced immune cell infiltration in local tumors and modulated cytokine levels in the peripheral blood, with distinct changes in the two treatment groups.
Based on these findings, both nsPEF ablation and PD-1 antibody administration can trigger a local and systemic immune response in a partially complementary manner, and nsPEF ablation should be considered along with PD-1 blockade for the treatment of HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yimingjiang, Maiweilidan& Tuergan, Talaiti& Chen, Xinhua& Wen, Hao& Shao, Yingmei& Zhang, RuiQing…[et al.]. 2020. Comparative Analysis of Immunoactivation by Nanosecond Pulsed Electric Fields and PD-1 Blockade in Murine Hepatocellular Carcinoma. Analytical Cellular Pathology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1126235
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yimingjiang, Maiweilidan…[et al.]. Comparative Analysis of Immunoactivation by Nanosecond Pulsed Electric Fields and PD-1 Blockade in Murine Hepatocellular Carcinoma. Analytical Cellular Pathology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1126235
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yimingjiang, Maiweilidan& Tuergan, Talaiti& Chen, Xinhua& Wen, Hao& Shao, Yingmei& Zhang, RuiQing…[et al.]. Comparative Analysis of Immunoactivation by Nanosecond Pulsed Electric Fields and PD-1 Blockade in Murine Hepatocellular Carcinoma. Analytical Cellular Pathology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1126235
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126235
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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