A Network Pharmacology Analysis to Explore the Effect of Astragali Radix-Radix Angelica Sinensis on Traumatic Brain Injury
المؤلفون المشاركون
Peng, Weijun
Wang, Yang
Xie, Genggeng
Li, Pengfei
Xia, Zian
Zhong, Yuanyuan
He, Feng
Tulake, Yimingaji
Feng, Dandan
Xing, Zhihua
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-25
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Traumatic brain injury (TBI) is a critical public health and socioeconomic problem worldwide.
The herb pair Astragali Radix (AR)-Radix Angelica Sinensis (RAS) is a common prescribed herbal formula or is added to other Chinese medicine prescriptions for traumatic brain injury (TBI) treatment.
However, the underlying mechanisms are unclear.
In this study, we aimed to explore the active ingredients and action targets of AR-RAS based on the combined methods of network pharmacology prediction and experimental verification.
Furthermore, the corresponding potential mechanisms of “multicomponents, multitargets, and multipathways” were disclosed.
Methods.
A network pharmacology approach including ADME (absorption, distribution, metabolism, and excretion) filter analysis, target prediction, known therapeutic targets collection, Gene Ontology (GO), pathway enrichment analysis, and network construction was used in this study.
Further verification experiments were performed to reveal the therapeutic effects of AR-RAS in a rat model of TBI.
Results.
The comprehensive systematic approach was to successfully identify 14 bioactive ingredients in AR-RAS, while 33 potential targets hit by these ingredients related to TBI.
Based on GO annotation analysis, multiple biological processes were significantly regulated by AR-RAS.
In addition, 89 novel signaling pathways (P<0.05) underlying the effects of AR-RAS for TBI treatment were identified by DAVID.
The neurotrophin signaling pathway was suggested as the major related pathway targeted by AR-RAS to improve axonal growth.
The animal experiment confirmed that AR-RAS significantly induced tissue recovery and improved neurological deficits on the 14th day (P<0.01).
Treatment with AR-RAS markedly reduced the protein and mRNA expression level of NogoA in the hippocampus of TBI rats.
Conclusion.
Our work illuminates the “multicompounds, multitargets, and multipathways” curative action of AR-RAS in the treatment of TBI by network pharmacology.
The animal experiment verifies the effects of AR-RAS on neurological function improvement and axonal outgrowth via downregulation of NogoA expression, providing a theoretical basis for further research on treatment of TBI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Pengfei& Xia, Zian& Zhong, Yuanyuan& He, Feng& Tulake, Yimingaji& Feng, Dandan…[et al.]. 2018. A Network Pharmacology Analysis to Explore the Effect of Astragali Radix-Radix Angelica Sinensis on Traumatic Brain Injury. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126240
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Pengfei…[et al.]. A Network Pharmacology Analysis to Explore the Effect of Astragali Radix-Radix Angelica Sinensis on Traumatic Brain Injury. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1126240
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Pengfei& Xia, Zian& Zhong, Yuanyuan& He, Feng& Tulake, Yimingaji& Feng, Dandan…[et al.]. A Network Pharmacology Analysis to Explore the Effect of Astragali Radix-Radix Angelica Sinensis on Traumatic Brain Injury. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126240
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126240
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر